Multivoxel pattern similarity suggests the integration of temporal duration in hippocampal event sequence representations

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Sathesan ThavabalasingamAndy C H Lee

Abstract

Recent rodent work suggests the hippocampus may provide a temporal representation of event sequences, in which the order of events and the interval durations between them are encoded. There is, however, limited human evidence for the latter, in particular whether the hippocampus processes duration information pertaining to the passage of time rather than qualitative or quantitative changes in event content. We scanned participants while they made match-mismatch judgements on each trial between a study sequence of events and a subsequent test sequence. Participants explicitly remembered event order or interval duration information (Experiment 1), or monitored order only, with duration being manipulated implicitly (Experiment 2). Hippocampal study-test pattern similarity was significantly reduced by changes to order or duration in mismatch trials, even when duration was processed implicitly. Our findings suggest the human hippocampus processes short intervals within sequences and support the idea that duration information is integrated into hippocampal mnemonic representations.

Citations

Jun 13, 2020·Journal of Cognitive Neuroscience·Jacob L S BellmundChristian F Doeller
Mar 14, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sathesan ThavabalasingamAndy C H Lee
Aug 7, 2019·ELife·Jacob Ls BellmundChristian F Doeller
Jan 1, 2019·Journal of Affective Disorders·Yifeng WangHuafu Chen
Jul 28, 2020·Neuroscience and Biobehavioral Reviews·Iva K BrunecMorgan D Barense
May 28, 2019·Trends in Cognitive Sciences·Lukas KunzNikolai Axmacher

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