Mumps serum antibody levels before and after an outbreak to assess infection and immunity in vaccinated students

Open Forum Infectious Diseases
Sigrid GoumaR van Binnendijk

Abstract

Since 2009, various mumps outbreaks have occurred in the Netherlands, affecting mostly young adults vaccinated against mumps. In this retrospective study, we estimated attack rates for symptomatic and asymptomatic mumps virus infection based on mumps-specific immunoglobulin (Ig)G concentrations in paired blood samples obtained before and after the mumps outbreaks, collected in 2 university cities. We aimed to identify a serological correlate of immune protection and risk factors for mumps virus infection. Mumps-specific IgG levels were measured by Luminex technology in paired pre- and post-outbreak samples from students from Leiden (n = 135) and Utrecht (n = 619). Persons with a 4-fold increase in mumps IgG concentrations or mumps IgG concentrations >1500 RU/mL were assumed to have had a mumps virus infection. Attack rates for symptomatic and asymptomatic mumps virus infection were 2.0% and 3.8%, respectively. Pre-outbreak mumps-specific IgG concentrations were lower among cases than among noncases (P = .005) despite vaccination history, but no serological cutoff for immune protection could be established. Mumps among housemates was significantly associated with serological evidence for mumps virus infection (odds ratio, 7.25 [...Continue Reading

References

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Citations

Mar 10, 2016·Vaccine·Sigrid GoumaRob S van Binnendijk
Mar 19, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Sabine VygenPatrick Rolland
Jun 6, 2015·Human Vaccines & Immunotherapeutics·Patricia KaaijkCécile A van Els
May 22, 2016·Infectious Diseases·Yoko AokiKatsumi Mizuta
Jul 28, 2016·Human Vaccines & Immunotherapeutics·Sigrid GoumaRob S van Binnendijk
Dec 30, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T-D LiJ Zhang
Jan 11, 2017·BMC Infectious Diseases·Susan HahnéHester de Melker
Apr 1, 2020·Expert Review of Vaccines·Gerco den HartogFiona R M van der Klis

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Software Mentioned

GraphPad Prism
SPSS

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