PMID: 7028917Jan 1, 1981Paper

Mumps-specific immunoglobulin M and G antibodies in natural mumps infection as measured by enzyme-linked immunosorbent assay

Journal of Medical Virology
P UkkonenK Penttinen

Abstract

An enzyme-linked immunosorbent assay for the demonstration of mumps immunoglobulin G (IgG ELISA) and immunoglobulin M antibodies (IgM ELISA) in serum was compared with complement fixation (CF), hemagglutination inhibition (HI), and hemolysis-in-gel (HIG) tests. The antibody levels measured by IgG ELISA had a high positive correlation with the CF and HIG tests, whereas only a moderate correlation was found between IgG ELISA and HI. Similar patterns of antibody response were observed with IgG ELISA, CF, and HIG: the antibody tires increased rapidly after the onset of symptoms and reached the maximal values in about three weeks. The HI antibodies developed more slowly during the first week of disease, after which the titres increased rapidly up to the fourth week. IgM antibodies measured by ELISA developed soon after onset of symptoms; most patients had IgM antibodies from the second day, and the highest titres were reached within the first week. The antibody response in mumps parotitis did not differ from that in mumps meningitis/encephalitis, while relatively higher antibody titres were found in patients with orchitis/epididymitis. The diagnostic efficiencies of the methods were compared with serum specimens from 33 patients who...Continue Reading

References

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Citations

May 1, 1993·Journal of Virological Methods·G A BerbersA D Plantinga
Dec 5, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Claudia H KrauseKate E Templeton
Jan 1, 1984·Journal of Medical Virology·M ZapataM A Chernesky
Jan 1, 1983·Scandinavian Journal of Infectious Diseases·O MeurmanP Hänninen
Dec 9, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leena N PatelJennifer B Rosen
Aug 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·G Glikmann, C H Mordhorst
Feb 28, 2020·Clinical Microbiology Reviews·Eugene LamJane R Zucker
Jan 25, 2018·Microbiology and Immunology·Sunil R VaidyaAtul M Walimbe
Aug 30, 2019·Journal of Family Medicine and Primary Care·Varun RehaniKulsaurabh Kaushik
Aug 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·G GlikmannC H Mordhorst

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