Mumps virus replication in human lymphoid cell lines and in peripheral blood lymphocytes: preference for T cells.

Infection and Immunity
B Fleischer, H W Kreth

Abstract

The replication of mumps virus was studied in human continuous lymphoblastoid cell lines (LCLs) with T or B characteristics and in lymphocyte subpopulations derived from peripheral blood. T-LCLs supported effective virus replication as shown by high titers of free and cell-associated virus over 1 to 4 days after infection. By immunofluorescence analysis, the majority of cells were positive for mumps virus antigens. In contrast, the B-cell lines produced low titers of infectious virus, and only a small percentage expressed viral antigens. This resistance of the B-LCLs was found with several mumps virus strains. Cultures of peripheral blood mononuclear cells also supported mumps virus replication. Very high titers of infectious virus (10(8) PFU/ml) were observed in cultures prestimulated with phytohaemagglutinin. Studies with enriched T and B cells point to the activated T lymphocyte as the major virus-producing cell.

References

Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·B R BloomL Jimenez
Jul 1, 1977·Vox Sanguinis·F Gmelig-Meyling, R E Ballieux
Dec 27, 1977·Medical Microbiology and Immunology·H I HuppertzV ter Meulen
Oct 1, 1978·The Journal of Experimental Medicine·C J LucasJ M Galama
Jun 15, 1974·International Journal of Cancer. Journal International Du Cancer·K Nilsson, C Sundström
Feb 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·F T WillemsW E Rawls
Jul 1, 1970·The Journal of Experimental Medicine·B R BloomP I Marcus
Aug 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·G KleinC Sundström
Jan 1, 1973·Advances in Immunology·E F Wheelock, S T Toy
Jan 1, 1970·Annual Review of Microbiology·A L NotkinsR J Howard
Jul 1, 1966·Journal of Bacteriology·H Duc-Nguyen, W Henle
May 1, 1970·The Journal of Pediatrics·T A KupersJ W St Geme
Oct 1, 1980·The Journal of General Virology·J K Chantler, A J Tingle
Feb 1, 1964·Lancet·J V PULVERTAFT

❮ Previous
Next ❯

Citations

Mar 11, 2020·International Journal of Environmental Research and Public Health·Shih-Bin SuAnd Kow-Tong Chen
Jan 1, 1986·Archives of Virology·H Müller
Jan 1, 1984·Archives of Virology·M TsurudomeY Ito
May 14, 2003·Journal of Virology·Christina M UlaneCurt M Horvath
Jul 28, 2016·Human Vaccines & Immunotherapeutics·Sigrid GoumaRob S van Binnendijk
Mar 18, 2008·Lancet·Anders HviidKathrin Mühlemann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.