Muramic acid detection in mammalian tissues by gas-liquid chromatography-mass spectrometry.

Infection and Immunity
A FoxT Cochran

Abstract

Muramic acid is a component of the peptidoglycan moiety of cell walls of all bacteria and blue-green algae and is not found elsewhere in nature. A gas-liquid chromatography-mass spectrometry assay for muramic acid in tissue is described. The application of the method to the detection of muramic acid in tissues of rats with streptococcal cell wall-induced polyarthritis is demonstrated. Because the method has the potential to measure total bacterial biomass in tissue, it should prove to be an important assay in elucidating the etiological role of bacterial debris in chronic inflammatory diseases in humans.

References

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Citations

Mar 1, 1984·Infection and Immunity·Z Sen, M L Karnovsky
Aug 12, 2003·Arthritis and Rheumatism·Xiang ZhangRobert D Inman
Jan 1, 1986·Infection and Immunity·S A StimpsonJ H Schwab
Oct 1, 1985·Infection and Immunity·J Harrison, A Fox
Jun 1, 1987·Infection and Immunity·J Gilbart, A Fox
Jan 1, 1995·Scandinavian Journal of Rheumatology. Supplement·M P Hazenberg
Nov 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A Fox

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Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.