PMID: 2111159Mar 1, 1990Paper

Muramyl dipeptide inhibits replication of human immunodeficiency virus in vitro

AIDS Research and Human Retroviruses
K N MasihiL Chedid

Abstract

In the search for compounds capable of inducing endogenous production of colony-stimulating factor (CSF) and possessing activity against human immunodeficiency virus (HIV), an immunomodulator, muramyl dipeptide (MDP), was investigated. MDP can enhance monocyte-macrophage CSF in serum and promote nonspecific resistance against a variety of microbial pathogens. MDP exhibited an inhibitory activity against HIV infection of CD4+ H9 lymphocytes and U937 monocytoid cells. An inhibitor of viral reverse transcriptase, 2', 3'-dideoxyadenosine, produced potent inhibition in cultures which were similarly infected with HIV. MDP could partially reduce antigen production in persistently HIV-infected KE37/1 lymphocyte cultures.

References

Jan 1, 1988·Hormone Research·S RöjdmarkG Kallner
Apr 1, 1988·Cellular Immunology·C D Pauza
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G C BaldwinD W Golde

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Citations

Jan 4, 2001·International Journal of Immunopharmacology·K N Masihi
Apr 25, 2000·International Journal of Antimicrobial Agents·K N Masihi
Jun 2, 2009·Nature Reviews. Drug Discovery·Kaoru GeddesStephen E Girardin
Jul 4, 2002·Immunology Letters·Ranjna C Dutta

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