Muramyl peptides and the functions of sleep

Behavioural Brain Research
J AndrenT K Roberts

Abstract

Muramyl peptides (MPs) are bacterially derived sleep factors which stimulate slow wave sleep. In the neonate, MPs are capable of inducing quiet sleep and suppressing active sleep. Given that active sleep is thought to be important for brain development during this period, the possibility that changes in the availability of MPs in the neonate may affect brain development was examined. Rat pups were given muramyl dipeptide (MDP) twice daily for the first 14 days post partum. It was hypothesised that MDP would stimulate quiet sleep at the expense of active sleep as has been shown in the young rabbit. There was no effect on neonatal levels of quiet sleep or active sleep. There was, however, a variety of effects, apparently unrelated to the sleep functions of MDP. These effects were changes in adult learning, serotonin metabolism and brain anatomy. The function of sleep in the mediation of the sleep-independent effects of MPs was examined, in particular the opposite effects of MDP on host immunity depending on the sleepiness of the host. In this light sleep does indeed serve to mediate the effects of MPs and it is speculated that many of the effects observed here may change in response to sleep levels in individuals. The notion that...Continue Reading

References

Jun 1, 1989·Neuron·Y A Barde
Jun 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H MoldofskyR Gorczynski
Dec 1, 1988·Current Opinion in Immunology
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·C Smith
Aug 1, 1971·The Journal of Physiology·V FenclJ R Pappenheimer
Apr 1, 1974·The Australian Journal of Experimental Biology and Medical Science·M C FooG N Cooper
Jan 1, 1970·Developmental Psychobiology·D Jouvet-MounierD Lacote
Mar 19, 1983·Lancet·R S Root-Bernstein, F C Westall
Jan 1, 1983·Experimental Brain Research·M L Jouandet, V Hartenstein
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M KruegerM L Karnovsky
Jun 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·L A TothJ M Krueger

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