Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses

Dose-response : a Publication of International Hormesis Society
Abhinav ParasharKelath Murali Manoj

Abstract

Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term "murburn" is abstracted from "muredburning" or "mildunrestrictedburning" and connotes a novel "molecule-unbound ion-radical" interaction paradigm. Quite unlike the genetic regulations and protein-level affinity-based controls that govern order and specificity/selectivity in conventional treatments, murburn concept is based on stochastic/thermodynamic regulatory principles. The novel insight necessitates a "reactivity outside the active-site" perspective, because select redox enzymatic activity is obligatorily mediated via diffusible radical/species. Herein, reactions employing key hemeproteins (as exemplified by CYP2E1) establish direct experimental connection between "additive-influenced redox catalysis" and "unusual dose responses" in reductionist and physiological milieu. Thus, direct and conclusive molecular-level experimental evidence is presented, supporting the mechanistic relevance of murburn concept in "maverick" concentration-based effects brought about by additives. Therefore, murburn concept could potentially explain several physiological hormetic and idiosyncratic dose responses.

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Citations

Nov 30, 2018·Journal of Biomolecular Structure & Dynamics·Kelath Murali ManojSurjith Ramasamy
Jan 22, 2020·Biomolecular Concepts·Kelath Murali Manoj
Mar 19, 2020·Biomolecular Concepts·Kelath Murali ManojKannan Pakshirajan
Jun 13, 2021·Progress in Biophysics and Molecular Biology·Kelath Murali Manoj, N M Bazhin
Jul 30, 2021·Journal of Biomolecular Structure & Dynamics·Kelath Murali ManojAfsal Manekkathodi
Aug 12, 2021·Journal of Cellular Physiology·Kelath Murali ManojHirohisa Tamagawa
Sep 14, 2021·Journal of Cellular Physiology·Kelath Murali Manoj, Hirohisa Tamagawa
Dec 18, 2021·Cell Biology International·Kelath Murali ManojLaurent Jaeken
Jan 14, 2022·Cell Biochemistry and Function·Kelath Murali ManojLaurent Jaeken

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

GraphPad Prism
BLAST

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