PMID: 8978019Jan 1, 1996Paper

Murine AIDS, a key to understanding retrovirus-induced immunodeficiency

Viral Immunology
B LiangRonald Ross Watson

Abstract

A murine AIDS model, induced by LP-BM5 murine leukemia virus (MuLV), has helped to investigate pathogenesis of acquired immunodeficiency syndrome (AIDS), cofactor involvement, and new treatment tests. LP-BM5 MuLV-infected mice characteristically develop hypergammaglobulinemia, splenomegaly, lymphadenopathy, T-cell functional deficiency, B-cell dysfunction, and, in the later stages, neurological signs including paralysis as well as susceptibility to opportunistic infections. The similarities between murine AIDS and human AIDS are striking, with similar changes in immune functions, T-cell differentiation, cytokine production, disease resistance, and oxidative stress. The well-characterized murine immunological system, availability of inbred strains, economy of using mice versus primate model, and similarities in immunodeficiency caused by human immunodeficiency virus (HIV) encouraged rapid development of the LP-BM5 murine AIDS model in the past decade.

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Citations

Jul 10, 2008·Immunogenetics·Suprawee TepsupornSharon A Stranford
Jan 16, 2002·International Immunopharmacology·Yingying LiuRonald Ross Watson
Aug 22, 2002·International Immunopharmacology·Qianli YuRonald R Watson
Aug 25, 2000·AIDS Research and Human Retroviruses·L Isaki, T F Kresina
Sep 1, 2001·Microbiology and Immunology·K YamaguchiW E Müller
Jul 4, 2002·International Immunopharmacology·Jin ZhangRonald Ross Watson
Jun 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Reshma S BaligaJohn A Bauer
Dec 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·R T SepúlvedaR R Watson
Jun 6, 2008·Expert Review of Proteomics·Rachel Van DuyneFatah Kashanchi
Jul 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Qianli YuDouglas F Larson
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·On Ho, William R Green

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