Nov 8, 2018

Murine bone properties and their relationship to gait during growth

BioRxiv : the Preprint Server for Biology
Hyunggwi SongMariana Elizabeth Kersh

Abstract

Allometric relationships have been queried over orders of mammals to understand how bone accommodates the mechanical demands associated with increasing mass. However, less attention has been given to the scaling of bone within a single lifetime. We aimed to determine if bone morphology and apparent density is related to (1) bending and compressive strength, and (2) gait dynamics. Longitudinal in vivo computed tomography and gait data were collected from female rats (n=5, age 8 - 20 weeks). Cross sectional properties and apparent density were measured at the diaphysis, distal, and proximal regions of the tibia and scaling exponents were calculated. Finite-element models were used to simulate four-point bending and axial compression using time-specific ground reaction forces (GRF) to calculate the mean strain energy density (SED) at the midshaft. Second moment of area at the diaphysis followed strain similarity based allometry, while bone area was positively allometric. The average SED at the diaphysis decreased, especially after the age of 10 weeks (R2=0.99), while it increased in compression (R2=0.96). The apparent density in all regions initially increased and converged by 11 weeks of age and this was correlated with changes i...Continue Reading

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Mentioned in this Paper

Diaphyses
In Vivo
Decompression Sickness
Murine
Science of Morphology
Ground Substance
X-Ray Computed Tomography
Bending - Changing Basic Body Position
Sustain
Finite Element Analysis

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