PMID: 9529320May 16, 1998Paper

Murine cytomegalovirus inhibits interferon gamma-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes

The Journal of Experimental Medicine
M T HeiseH W Virgin

Abstract

CD4 T cells and interferon gamma (IFN-gamma) are required for clearance of murine cytomegalovirus (MCMV) infection from the salivary gland in a process taking weeks to months. To explain the inefficiency of salivary gland clearance we hypothesized that MCMV interferes with IFN-gamma induced antigen presentation to CD4 T cells. MCMV infection inhibited IFN-gamma-induced presentation of major histocompatibility complex (MHC) class II associated peptide antigen by differentiated bone marrow macrophages (BMMphis) to a T cell hybridoma via impairment of MHC class II cell surface expression. This effect was independent of IFN-alpha/beta induction by MCMV infection, and required direct infection of the BMMphis with live virus. Inhibition of MHC class II cell surface expression was associated with a six- to eightfold reduction in IFN-gamma induced IAb mRNA levels, and comparable decreases in IFN-gamma induced expression of invariant chain (Ii), H-2Ma, and H-2Mb mRNAs. Steady state levels of several constitutive host mRNAs, including beta-actin, cyclophilin, and CD45 were not significantly decreased by MCMV infection, ruling out a general effect of MCMV infection on mRNA levels. MCMV effects were specific to certain MHC genes since IFN-...Continue Reading

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Citations

Jun 1, 2005·Trends in Immunology·Hartmut HengelKarl-Klaus Conzelmann
Nov 19, 2003·Microbes and Infection·Astrid KrmpoticStipan Jonjic
Feb 27, 1999·Current Opinion in Immunology·D M Miller, D D Sedmak
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Jan 13, 2009·Virology Journal·Mindy Miller-Kittrell, Tim E Sparer
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Daniel L PopkinHerbert W Virgin
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