Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver

The Journal of Immunology : Official Journal of the American Association of Immunologists
E QuattrocchiM Feldmann

Abstract

The effects of homologous IL-10 administration during an established autoimmune disease are controversial, given its reported immunostimulatory and immunosuppressive properties. Studies of collagen-induced arthritis have shown efficacy with repeated administrations of IL-10; however, when the EBV IL-10 homologue was administered via adenovirus gene transfer technology the results were equivocal. Therefore, the present study was undertaken to elucidate the effects of prolonged homologous IL-10 administration via adenovirus-mediated gene delivery on the progression of established arthritis. Collagen type II (CII)-immunized mice received i.v. injections of 10(7) or 10(8) PFU of an E1-deleted adenoviral vector containing the murine IL-10 gene (AdIL-10), after arthritis onset. Mice were monitored for 3 wk for disease progression, and gene transduction was assessed by quantification of serum mIL-10. CII-specific cell-mediated and humoral immune responses were analyzed by lymph node cell proliferation, cytokine production, and anti-CII Ab responses. Furthermore, because adenoviral vectors have been reported to induce organ dysfunction due to cell-mediated immune responses to the viral Ags, we have also evaluated delayed-type hypersens...Continue Reading

References

Aug 1, 1992·Nature Genetics·H A JaffeM Perricaudet
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·F RoussetJ Banchereau
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R O WilliamsR N Maini
Mar 1, 1992·European Journal of Immunology·A O'GarraM Howard
Feb 1, 1991·The Journal of Experimental Medicine·L Thompson-SnipesD M Rennick
Dec 1, 1990·Immunological Reviews·R HolmdahlJ A Mo
Jun 1, 1994·European Journal of Immunology·O RottE Cash
Oct 1, 1995·Current Opinion in Biotechnology·J L BramsonJ Gauldie
Jan 1, 1995·Arthritis and Rheumatism·J J CushP E Lipsky
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·J F EngelhardtJ M Wilson
May 1, 1994·The Journal of Experimental Medicine·P D KatsikisM Feldmann
May 1, 1994·Clinical Immunology and Immunopathology·K J PennlineM Monahan
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y YangJ M Wilson
Feb 1, 1994·The Journal of Experimental Medicine·F BrièreJ Banchereau
Jan 1, 1993·Annual Review of Immunology·K W MooreT R Mosmann
Mar 1, 1996·Arthritis and Rheumatism·M WalmsleyM Feldmann
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
Apr 1, 1996·Journal of Autoimmunity·B Balasa, N Sarvetnick
Jun 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Y TanakaY Niho
Feb 10, 1997·Human Gene Therapy·T J RussiR G Crystal
Mar 17, 1999·The Journal of Experimental Medicine·D J CuaR L Coffman
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K N KimR Hirsch
Mar 16, 2000·The New England Journal of Medicine·D S Pisetsky
Apr 25, 2000·Annual Review of Medicine·R N Maini, P C Taylor
Jan 1, 1991·Methods in Molecular Biology·F L Graham, L Prevec

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Citations

Sep 11, 2002·Oral Diseases·J M Vitolo, B J Baum
Nov 20, 2002·The Journal of Gene Medicine·Natacha BessisMarie-Christophe Boissier
Jan 23, 2003·The Journal of Gene Medicine·Nathalie Saidenberg-Kermanac'hMarie-Christophe Boissier
Dec 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qingfeng ChenZhigang Tian
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francisco J QuintanaIrun R Cohen
Apr 6, 2006·World Journal of Gastroenterology : WJG·Li-Juan Zhang, Xiao-Zhong Wang
Apr 25, 2012·Mediators of Inflammation·Tiina KelkkaRikard Holmdahl
Jun 2, 2016·Immunological Investigations·M E Castañeda-LopezM L Martinez-Fierro
Dec 1, 2001·Expert Opinion on Biological Therapy·E GouzeC H Evans
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keishi FujioKazuhiko Yamamoto

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