PMID: 11604588Oct 18, 2001Paper

Murine lupus genetics: lessons learned

Current Opinion in Rheumatology
C Mohan

Abstract

Recent reverse genetic studies in murine lupus have taught us the following lessons: (1) Lupus is extremely polygenic; (2) A single locus may be associated with many different phenotypes; (3) What appears to be a single locus may turn out to be a cluster of loci; (4) Different loci facilitate different immunologic steps leading to lupus; (5) Epistatic interactions between loci may engender novel autoimmune phenotypes; (6) Whereas some loci may be pathogenic, others may confer disease resistance; (7) Whereas the expression of some loci is sex-dependent, the expression of others clearly is not; (8) Two or more loci may have an impact on the same phenotype; (9) Lupus susceptibility loci appear to co-cluster with other autoimmunity susceptibility loci; (10) Lupus genes are likely to be polymorphic alleles with subtle impacts, rather than outright mutations with extreme functions. In contrast, forward genetic studies have revealed that molecules that impact apoptosis, the clearance of apoptotic cells, B-cell or T-cell function, and end-organ pathology can all potentially contribute to lupus. Collectively, the loci and genes identified by these two different approaches factorize into a few distinct pathways leading to lupus. Delineat...Continue Reading

References

Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A StrasserA W Harris
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·D H KonoA N Theofilopoulos
Oct 15, 1996·The Journal of Clinical Investigation·T J VyseB L Kotzin
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·S J RozzoB L Kotzin
Mar 21, 1998·The Journal of Clinical Investigation·S VidalA N Theofilopoulos
Feb 14, 1998·Kidney International·R J QuiggM C Carroll
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·K G BeckerJ M Trent
Sep 17, 1998·The Journal of Clinical Investigation·S Y ParkT Saito
Oct 17, 1998·Journal of the American Society of Nephrology : JASN·U JanssenJ Floege
Oct 20, 1998·Immunobiology·M J WalportM Botto
Nov 10, 1998·European Journal of Immunology·J JirholtR Holmdahl
Jan 23, 1999·Current Opinion in Immunology·R Holmdahl
Jan 29, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L MorelE K Wakeland
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·R A McIndoeL Hood
Jun 22, 1999·The Journal of Clinical Investigation·C MohanE K Wakeland
Aug 12, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·N D MeekerC Teuscher
Sep 25, 1999·Science·A Di CristofanoP P Pandolfi
Dec 10, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A SchwartingV R Kelley
Jan 13, 2000·Current Opinion in Immunology·M M GriffithsR L Wilder
Jan 13, 2000·Current Opinion in Immunology·E K WakelandL Morel

❮ Previous
Next ❯

Citations

Oct 22, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael Walsh, David Jayne
Mar 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shangkui Xie, Chandra Mohan
Sep 11, 2002·Molecular Immunology·Leian ChenChandra Mohan
Apr 26, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Aleth PerdrigerKarine Rollot-Elamrani
Aug 7, 2002·The Journal of Experimental Medicine·Xiaoyan ShiChandra Mohan
Mar 23, 2004·Annual Review of Immunology·Anthony P MandersonMark J Walport
Oct 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Loren D EricksonRandolph J Noelle
Sep 12, 2003·Current Rheumatology Reports·Jennifer AnolikR John Looney
Mar 31, 2009·Journal of Autoimmunity·Robert Eisenberg
Mar 7, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kui Liu, Chandra Mohan
Jun 5, 2013·Genomics, Proteomics & Bioinformatics·Yajuan LiQuan-Zhen Li
Apr 14, 2007·Orvosi hetilap·Edit BuzásGyula Szegedi
Jun 11, 2004·Immunity·Carola G Vinuesa, Christopher C Goodnow
Jan 17, 2003·Lupus·L E SchifferA Davidson
Sep 7, 2002·Genes and Immunity·S XieC Mohan
Sep 1, 2007·Arthritis and Rheumatism·Xiaoyan ShiChandra Mohan
Oct 4, 2005·Arthritis and Rheumatism·Jianwei LiChandra Mohan
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geeta RaiBarbara A Newman
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Borna MehradChandra Mohan
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S XieC Mohan
Nov 6, 2004·Arthritis and Rheumatism·Jennifer H AnolikIñaki Sanz
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong XinDivaker Choubey
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ching ChenMartin Weigert
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luigia PaceGino Doria
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chun XieChandra Mohan
Jan 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simanta PathakChandra Mohan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

International Reviews of Immunology
L Morel, E K Wakeland
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Huifang TangHongwei Gao
© 2021 Meta ULC. All rights reserved