Murine model for therapy of listeriosis in the compromised host. I. Effect of ampicillin

Chemotherapy
H HofH P Seeliger

Abstract

Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal mice. In nude mice with chronic listeriosis, treatment with ampicillin was started 8 days after infection. The numbers of viable listeria cells decreased under therapy, but a bacteriologic cure was not achieved in a 6-day schedule. Relapse followed cessation of therapy.

Citations

Jan 1, 1983·Medical Microbiology and Immunology·H Hof
Jan 1, 1991·International Journal of Immunopharmacology·G DickneiteH H Sedlacek
Nov 1, 1984·The Journal of Infection·B Kawaler, H Hof
Jul 1, 1986·The Journal of Infection·H Hof
Jan 21, 2004·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Manuel L Fernández GuerreroJorge Martinell
Mar 22, 2003·FEMS Immunology and Medical Microbiology·H Hof

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