Murine models of autoimmune hemolytic anemia

Current Opinion in Hematology
Heather L Howie, Krystalyn E Hudson

Abstract

Pathogenic autoantibodies directed against red blood cells (RBCs) may lead to autoimmune hemolytic anemia (AIHA), a severe and sometimes fatal disease. Much of what is known about the etiology and pathogenesis of AIHA has been learned from observations made in human patients and murine models, but many questions remain; importantly, it is still unclear why some people generate RBC-specific autoantibodies. The combination of technological advancements applied to existing models and the development of new AIHA murine models will continue to provide considerable insight into the initiation of AIHA and provide a platform for the design of more effective therapies. Advancements in well described murine models of AIHA show that reticulocytes are preferentially targeted by anti-RBC autoantibodies and an increase in oxidative stress may trigger autoantibody production. Additionally, a new murine model of erythrocyte autoreactivity demonstrates that T cell tolerance is the stopgap for autoimmunity. Moreover, unlike many self-antigens, data suggest that RBC self-antigens are not presented in the thymus thereby escaping the scrutiny of T cell central tolerance mechanisms and placing emphasis on peripheral tolerance instead. Information ga...Continue Reading

References

Oct 1, 1979·Journal of Clinical Pathology·J Freedman
Jan 1, 1992·The Journal of Experimental Medicine·M OkamotoT Honjo
Mar 22, 1985·JAMA : the Journal of the American Medical Association·I A ShulmanL D Petz
Jun 13, 1973·Nature: New Biology·J H Playfair, S Marshall-Clarke
Apr 1, 1973·Clinical Immunology and Immunopathology·N L Warner
Jan 1, 1968·Advances in Immunology·J B Howie, B J Helyer
Jan 1, 1983·Clinical and Laboratory Haematology·F StrattonE E Thomson
Feb 1, 1980·Vox Sanguinis·D W GorstF Stratton
Aug 1, 1994·Critical Reviews in Oncology/hematology·S IzuiT Berney
Aug 1, 1996·Clinical and Experimental Immunology·G G de Sá OliveiraR N Barker
Aug 8, 2002·Clinical and Experimental Immunology·R N BarkerC J Elson
Apr 1, 1963·British Journal of Haematology·B J HELYER, J B HOWIE
Jan 19, 2010·Free Radical Biology & Medicine·Yoshihito IuchiJunichi Fujii
Jun 16, 2010·Blood·Klaus Lechner, Ulrich Jäger
Sep 11, 2012·Experimental Hematology·Lin XuTao Ren
Oct 8, 2013·Free Radical Biology & Medicine·Tasuku KonnoJunichi Fujii
Mar 29, 2014·Asian Journal of Transfusion Science·R K Chaudhary, Sudipta Sekhar Das
Dec 17, 2014·Autoimmunity Reviews·Quitterie ReynaudJean-Christophe Lega
Dec 24, 2015·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Charles H Packman
Oct 5, 2016·Frontiers in Immunology·Amanda L RichardsKrystalyn E Hudson
Apr 1, 2017·Blood·Ronald S GoNeil E Kay
Nov 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole Baumgarth

❮ Previous
Next ❯

Citations

Dec 10, 2020·Immunity & Ageing : I & a·Sylwia Sulimiera MichalakLidia Gil
Dec 17, 2020·Journal of Clinical Medicine·Irina Murakhovskaya
May 1, 2021·International Journal of Molecular Sciences·Ting-Ting Sheu, Bor-Luen Chiang
Dec 7, 2021·Frontiers in Immunology·Flavia Dei ZottiKrystalyn E Hudson

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
dissection

Software Mentioned

IgHEL
OTII
SwHEL

Related Concepts

Related Feeds

Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.