PMID: 8958939Oct 31, 1996Paper

Murine models of cancer cytokine gene therapy using interleukin-12

Annals of the New York Academy of Sciences
H TaharaM T Lotze

Abstract

Cytokine gene therapy, in particular IL-12 gene therapy, is one of the more novel and promising approaches in cancer therapy based on significant preclinical data derived mainly from murine tumor models. IL-12 is a heterodimeric cytokine that requires the simultaneous expression of both the p35 and p40 chains from the same cell for production of biologically active IL-12. A variety of biological functions have been attributed to IL-12 including the induction of IFN-gamma production and the promotion of predominantly Th1-type immune responses to antigens. Our previous studies using systemic administration of recombinant murine IL-12 have demonstrated profound antitumor efficacy against all tumors tested with the concomitant long-lived specific antitumor immunity in some cases. To determine whether the local secretion of IL-12 achieved by gene transduction has significant antitumor effects, fibroblast cell lines or murine tumor cell lines were transduced with expression plasmids or the retroviral vector TFG-mIL-12-Neo and inoculated intradermally (i.d.). Our first study using IL-12-transfected NIH3T3 cells admixed with the murine melanoma, BL-6, showed that local IL-12 expression suppresses tumor growth and promotes the acquisiti...Continue Reading

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Citations

Jun 1, 2000·Medical & Biological Engineering & Computing·B Chevallay, D Herbage
Nov 6, 1998·Pharmacology & Therapeutics·P D Robbins, S C Ghivizzani
Mar 6, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·James W YockmanSung Wan Kim
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Nov 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D G Mack, H A Jaffe
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Nov 3, 2006·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Farzan SiddiquiRobert L Ullrich
May 31, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ying LiuHua Jiang
Feb 19, 2002·The Journal of Pharmacy and Pharmacology·A QuezadaM Coleman
Feb 12, 2004·Cancer Research·Masayuki HisadaTakayuki Yoshimoto
Feb 12, 2004·Cancer Research·Qingsheng LiShu-Hsia Chen

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