Murine monoclonal anti-myelin basic protein (MBP) antibodies inhibit proliferation and cytotoxicity of MBP-specific human T cell clones.

Journal of Neuroimmunology
J W ZhangJ C Raus

Abstract

Myelin basic protein (MBP)-specific T cell clones, isolated from two patients with multiple sclerosis, expressed the CD4+ phenotype and induced MBP-dependent cytolysis of autologous Epstein-Barr virus (EBV)-transformed B cells. The proliferation and cytolytic activity of the T cell clones were inhibited by four of a panel of five murine monoclonal anti-MBP antibodies in a dose-dependent manner. An isotype-matched antibody with an irrelevant specificity did not have such an effect. These MBP-specific monoclonal antibodies did not block phytohemagglutinin-induced T cell proliferation or allospecific cytotoxicity. These results suggest that some antibodies directed at the autoantigen MBP may play a regulatory role in T cell activation, rather than a pathogenic role, for which there is currently little supporting evidence.

References

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Citations

Jan 15, 1996·The Journal of Clinical Investigation·F S GalinJ E Blalock
Sep 1, 1989·Journal of Neuroimmunology·J W ZhangJ C Raus
Apr 15, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Stefanie KuertenPaul V Lehmann
Jan 1, 1992·International Reviews of Immunology·J ZhangD A Hafler

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