PMID: 12416031Nov 6, 2002Paper

Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander

Journal of Experimental Therapeutics & Oncology
Dan NiR A Newman


Pharmacokinetic studies of [3H]oleandrin, a cardiac glycoside component of Anvirzel, were conducted in mice after either an i.v. dose (40 micrograms/kg) or a p.o. dose (80 micrograms/kg). Oleandrin was rapidly absorbed after oral dosing (Cmax at 20 min) although the elimination half-life was longer (2.3 +/- 0.5 h) than that after i.v. dosing (0.4 +/- 0.1 h). The AUC0-infinity values obtained after i.v. and p.o. dosing were 24.6 +/- 11.1 and 14.4 +/- 4.3 (ng.h/ml), respectively, resulting in an oral bioavailability of approximately 30%. After i.v. administration, oleandrin concentration in liver was approximately twice that measured in heart or kidney tissue. Oleandrigenin, the aglycone of oleandrin, was also found in these tissues. At 5 min, > 60% of the total radioactivity in liver was due to oleandrin while 28% of the given dose was present as oleandrigenin. Twenty-four hours following injection, 8% of total radioactivity was excreted in urine and contained both oleandrigenin (4.4% of the injected dose) and oleandrin (1.9%). Sixty-six percent of injected radioactivity was found in feces and consisted of oleandrin and oleandrigenin in equal amounts. Uptake of oleandrin in brain after i.p. injection of oleandrin (3 mg/kg) or ol...Continue Reading


Jan 25, 2007·Tropical Animal Health and Production·B Soto-BlancoJ E Nóbrega
Nov 23, 2007·Research in Veterinary Science·R R BarbosaB Soto-Blanco
Sep 8, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Leslie W WoodsBirgit Puschner
Feb 1, 2018·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Anselm Wong, Shaun L Greene
Jan 5, 2020·Neurological Research·Sule Terzioglu-UsakMustafa Aziz Hatiboglu
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nazia KanwalZeliha Selamoglu
Dec 12, 2018·Toxicon : Official Journal of the International Society on Toxinology·Ana Flávia M BotelhoMarília Martins Melo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Related Papers

Tropical Animal Health and Production
B Soto-BlancoJ E Nóbrega
Pacing and Clinical Electrophysiology : PACE
Wojciech Wojtyna, Frank Enseleit
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
R J BickO Howard Frazier
© 2022 Meta ULC. All rights reserved