PMID: 15356121Sep 10, 2004Paper

Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement

The Journal of Immunology : Official Journal of the American Association of Immunologists
Francesca FallarinoPaolo Puccetti

Abstract

In this study, using a soluble CD200-Ig fusion protein, we provide evidence that murine dendritic cells (DCs) possess a functional CD200R, whose engagement results in the reinforcement or appearance of immunosuppressive properties in these cells. In particular, the plasmacytoid subset (CD11c+B220+120G8+) of splenic DCs (pDCs) is induced by CD200-Ig to express the enzyme IDO, which initiates the tolerogenic pathway of tryptophan catabolism. As a result, pDCs are capable of suppressing Ag-specific responses in vivo when transferred into recipient hosts after treatment with CD200-Ig. IDO induction in pDCs through CD200R engagement requires type I IFNR signaling. Although the release of IFN-alpha may contribute to the full expression of CD200-Ig activity, autocrine IFN-alpha is unlikely to mediate alone the effects of CD200R engagement. These data prospect novel functions for both pDCs and the CD200-CD200R pair in the mouse. At the same time, these data underscore the possible unifying role of the IDO mechanism in immune tolerance.

References

Mar 2, 1999·Molecular Human Reproduction·K A KaufmanC Ober
Sep 29, 1999·Immunology Today·A L Mellor, D H Munn
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U GrohmannP Puccetti
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U GrohmannP Puccetti
Mar 29, 2001·Nature Immunology·C Nathan, W A Muller
Mar 27, 2001·Transplantation Proceedings·T MikiL A Valdivia
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·U GrohmannP Puccetti
Nov 20, 2001·Nature Immunology·C Asselin-PaturelG Trinchieri
Dec 1, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R M GorczynskiJ Hu
Dec 26, 2001·International Immunology·Francesca FallarinoPaolo Puccetti
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ralph Marvin Steinman, Michel C Nussenzweig
Feb 21, 2002·The Journal of Experimental Medicine·Winfried BarchetUlrich Kalinke
Mar 5, 2002·Nature·Gloria Martínez del HoyoCarlos Ardavín
Mar 27, 2002·Nature Reviews. Immunology·Ken Shortman, Yong-Jun Liu
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Laura BelladonnaPaolo Puccetti
Jun 20, 2002·Trends in Immunology·A Neil BarclayMarion H Brown
Aug 6, 2002·Journal of Neuroimmunology·Kenichi SakuraiGene M Shearer
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dagmar von BubnoffThomas Bieber
Sep 27, 2002·American Journal of Reproductive Immunology : AJRI·Reginald M GorczynskiDavid A Clark
Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
Feb 28, 2003·Biology of Reproduction·Margaret G PetroffJoan S Hunt
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miren KerkmannGunther Hartmann
May 3, 2003·Trends in Molecular Medicine·Ursula Grohmann, Paolo Puccetti
May 10, 2003·Trends in Immunology·Ursula GrohmannPaolo Puccetti
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L Mellor, David H Munn
Jul 2, 2003·The Journal of Experimental Medicine·Ursula GrohmannPaolo Puccetti
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L MellorDavid H Munn
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ursula GrohmannPaolo Puccetti
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gavin J WrightA Neil Barclay
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Nov 25, 2003·American Journal of Reproductive Immunology : AJRI·David A ClarkReginald M Gorczynski
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carine Asselin-PaturelGiorgio Trinchieri
Jan 16, 2004·Gastroenterology·Gregory J GurtnerWilliam F Stenson
Jan 27, 2004·Journal of Leukocyte Biology·Nicholas J MegjugoracPatricia Fitzgerald-Bocarsly
Feb 6, 2004·Nature Immunology·Varuna R AluvihareAlexander G Betz
Mar 3, 2004·The Journal of Clinical Investigation·Marco Colonna

❮ Previous
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Citations

Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria C JenmalmJonathon D Sedgwick
Oct 13, 2005·Current Opinion in Gastroenterology·Jan Hendrik Niess, Hans-Christian Reinecker
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria L BelladonnaPaolo Puccetti
Jan 31, 2008·Acta Clinica Belgica·B N Lambrecht
Sep 19, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexey Popov, Joachim L Schultze
Sep 4, 2007·Nature Reviews. Immunology·Paolo Puccetti, Ursula Grohmann
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Reg GorczynskiIvo Boudakov
Feb 7, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Vito R CicinnatiSusanne Beckebaum
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei ChenBruce R Blazar
Jul 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Reginald M GorczynskiIvo Boudakov
Feb 5, 2009·Clinical & Developmental Immunology·Jorge Schettini, Pinku Mukherjee
Jul 16, 2009·Journal of Cellular and Molecular Medicine·Anika MüllerWalter Däubener
Mar 11, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alla L ZozulyaHeinz Wiendl
Jul 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia VolpiMaria L Belladonna
Dec 30, 2014·Oncotarget·Lorenzo GalluzziGuido Kroemer
Jul 15, 2015·Nature Reviews. Immunology·Melissa Swiecki, Marco Colonna
Jul 18, 2015·Clinical Science·Amanda W S YeungShane R Thomas
Aug 23, 2016·American Journal of Reproductive Immunology : AJRI·Chunyu HuangYong Zeng
Sep 25, 2017·American Journal of Reproductive Immunology : AJRI·Jie XuYuping Wang
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ikuo ShiratoriHisashi Arase
Dec 17, 2005·European Journal of Immunology·Francesca Fallarino, Paolo Puccetti
Oct 4, 2005·Expert Opinion on Biological Therapy·Pawel KalinskiRonald B Herberman
Jul 25, 2006·Nature Reviews. Cancer·Alexander J Muller, Peggy A Scherle
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ciriana OrabonaPaolo Puccetti
Nov 19, 2004·Nature Immunology·Marco ColonnaYong-Jun Liu
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·John R McWhirterKatherine S Bowdish
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anke Kretz-RommelKatherine S Bowdish
Aug 22, 2008·Immunological Investigations·Joan K Riley
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Creg J WorkmanDario A A Vignali
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hee-Kap KangSyamal K Datta
Sep 21, 2010·European Journal of Immunology·Melissa Swiecki, Marco Colonna
Apr 24, 2012·Allergy·D von Bubnoff, T Bieber
May 16, 2013·Nature Communications·Claudia VolpiPaolo Puccetti
Dec 23, 2015·International Journal of Molecular Sciences·Mohamed F ElshalJ Philip McCoy
Jul 8, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin-Qing LiuXue-Feng Bai
Mar 16, 2018·Frontiers in Immunology·Emilia VendelovaManfred B Lutz

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