PMID: 6978566May 1, 1982Paper

Murine respiratory mycoplasmosis in LEW and F344 rats: strain differences in lesion severity

Veterinary Pathology
J K Davis, G H Cassell

Abstract

Pathogen-free weaning rats of the LEW and F344 strains were caged together for two months to eliminate microbial and environmental differences, and then infected intranasally with 10-fold dilutions of viable Mycoplasma pulmonis. At necropsy 28 days post-inoculation, F344 rats had no gross lung lesions, even those given the maximum dose of 1.4 X 10(9) colony-forming units of M. pulmonis. LEW rats often had extensive gross lesions with a gross-pneumonia-dose50 of 1.1 X 10(7) colony-forming units/rat. Histological examination of the respiratory tract (nasal passages, larynges, tracheae, and lungs) and tympanic cavities showed both qualitative and quantitative differences in lesions between the two strains, particularly in the lungs. Hyperplasia of bronchus-associated lymphoid tissue occurred in both strains, but was more extensive in LEW rats. Atelectasis, alveolar consolidation (due primarily to mononuclear inflammatory cells), and suppurative bronchitis and bronchiolitis were seen only in LEW rats. Infiltrates of lymphoid cells into the lungs distal to bronchi and around blood vessels also were seen primarily in LEW rats. These differences between the two rat strains provide excellent model systems with which to dissect the role...Continue Reading

References

Nov 1, 1977·Infection and Immunity·Y NaotH Ginsburg
Dec 1, 1978·Nihon juigaku zasshi. The Japanese journal of veterinary science·M SaitoK Imaizumi
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Feb 1, 1976·Journal of Immunogenetics·N Tada Aizawa
Jan 1, 1974·Pathologia et microbiologia·E A Freundt
Aug 1, 1980·Infection and Immunity·J K DavisG H Cassell

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Citations

Nov 1, 1992·Mechanisms of Ageing and Development·M J Steffen, J L Ebersole
Mar 1, 1995·Mechanisms of Ageing and Development·M J Steffen, J L Ebersole
Oct 1, 1985·Veterinary Immunology and Immunopathology·C J Howard, G Taylor
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Sep 26, 2013·The Journal of Veterinary Medical Science·Atsushi AsanoTakashi Agui
Jul 8, 1999·The American Journal of Pathology·T J MurphyD M McDonald
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Harlan P JonesJerry W Simecka
Mar 12, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jamie L RothenburgerClaire M Jardine
Oct 1, 1986·Infection and Immunity·J K DavisG H Cassell
Jul 1, 1992·Infection and Immunity·J C McIntoshG H Cassell
Jan 1, 1995·Infection and Immunity·Z LapidotY Naot
Feb 1, 1992·Infection and Immunity·M J Steffen, J L Ebersole
May 6, 2010·Archives of Pathology & Laboratory Medicine·Donald G Guinee
Dec 1, 1996·Infection and Immunity·S C CartnerJ R Lindsey
Jul 1, 1985·Human Pathology·S A YousemC B Carrington

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