Murine-specific Internal Dosimetry for Preclinical Investigations of Imaging and Therapeutic Agents

Health Physics
Bryan BednarzMario Otto

Abstract

There is a growing need to estimate the absorbed dose to small animals from preclinical investigations involving diagnostic and therapeutic radiopharmaceuticals. This paper introduces a Monte Carlo-based dosimetry platform called RAPID, which is capable of calculating murine-specific three-dimensional (3D) dose distributions. A comparison is performed between absorbed doses calculated with RAPID and absorbed doses calculated in a commonly used reference mouse phantom called MOBY. Four test mice containing different xenografts underwent serial PET/CT imaging using a novel diagnostic therapy (theranostic) agent NM404, which can be labeled with I for imaging or I for therapy. Using the PET/CT data, 3D dose distributions from I-NM404 were calculated in the mice using RAPID. Mean organ doses in these four test mice were compared to mean organ doses derived by using two previously published I S-values datasets in MOBY. In addition, mean tumor doses calculated in RAPID were compared to mean organ doses derived from unit density spheres. Large differences were identified between mean organ doses calculated in the test mice using RAPID and those derived in the MOBY phantom. Mean absorbed dose percent errors in organs ranged between 0.3%...Continue Reading

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Citations

May 8, 2020·Nuclear Medicine and Molecular Imaging·Arun GuptaJae Sung Lee
Apr 8, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joseph J GrudzinskiJamey Weichert
Jun 16, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lukas M CarterJason S Lewis

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