Murine strain differences in 8-hydroxy-deoxyguanosine formation in hepatic DNA induced by oxidized lard and dietary oils

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
K SadakaneT Shibamoto

Abstract

Difference of 8-hydroxy-deoxyguanosine (8-OH-dG) formation in liver DNA in C3H/HeN and in C57BL/6 mice--fed oxidized lard and dietary oils (soybean and sardine)--was investigated. The blank levels of 8-OH-dG were higher in C3H/HeN mice (highly sensitive to liver tumorigenesis) than in C57BL/6 mice (resistant strain). The level of 8-OH-dG increased much more in C3H/HeN mice than in the C57BL/6 mice fed by oxidized lard and dietary oil treatment. Feeding oxidized lard and dietary oils increased 8-oxo-guanine DNA glycosylase I (OGG1) and mRNA 8-oxo-dGTPase in C57BL/6 mice. On the other hand, no appreciable change of mRNA in the C3H/HeN mice was observed. The formation differences of 8-OH-dG from the two murine strains fed with oxidized lard and dietary oils may be associated with the different mRNA levels in the DNA repair enzymes because the mRNA levels in the DNA repair enzymes were much lower in C3H/HeN mice than in C57BL/6 mice.

References

Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·T A RosenquistA P Grollman
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·J P RadicellaS Boiteux
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·T TsuzukiM Sekiguchi
Sep 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T IchinoseT Shibamoto
Oct 28, 2004·Lipids·Kazutoshi Fujioka, Takayuki Shibamoto

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Citations

Oct 12, 2010·The Journal of Toxicological Sciences·Ryo KobayashiHisamitsu Nagase
Apr 23, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabine A S LangieJohn C Mathers

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