PMID: 6164731Jun 1, 1981Paper

Murine transfer factor. I. Description of the model and evidence for specificity

The Journal of Immunology : Official Journal of the American Association of Immunologists
E A PetersenC H Kirkpatrick

Abstract

A model for studying transfer of delayed-type sensitivity to mice with cellfree materials is described. The results with a particulate antigen (Candida) and 4 soluble protein antigens (PPD, ferritin, cytochrome c, and horseradish peroxidase) suggest that the phenomenon is antigen specific. Identical preparations from the spleens of insensitive donors were not active. This murine model should facilitate characterization of the immunologic and chemical properties of transfer factor.

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