PMID: 3753539Sep 1, 1986Paper

Murine type II collagen arthritis. Association of an acute-phase response with clinical course

Arthritis and Rheumatism
M L BlivenI G Otterness

Abstract

The acute-phase reactant, C-reactive protein, is a good index of disease activity in patients with rheumatoid arthritis. We examined the murine acute-phase reactant, serum amyloid P, as an index of disease in type II collagen-induced arthritis in 3 mouse strains. The onset of type II collagen-induced arthritis, which is characterized by paw swelling, is associated with a significant, but transient, elevation of serum amyloid P. Anticollagen antibody titers are not temporally associated with the onset of disease. Although murine type II collagen arthritis fails to show the chronic acute-phase reactant elevation that is characteristic of arthritis in humans, the transient elevation of the acute-phase reactant is a reliable indicator of the onset of disease.

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Citations

Jun 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Y TanakaY Niho
Feb 1, 1994·International Journal of Immunopharmacology·F NishikakuY Koga
Jul 27, 1999·Annals of the Rheumatic Diseases·C J SchaeferP H Wooley
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Nov 1, 1988·Arthritis and Rheumatism·D E GriswoldN Hanna
Jun 1, 1997·Arthritis and Rheumatism·C J SchaeferP H Wooley
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R O WilliamsR N Maini

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