Murine Typhus in South Texas Children: An 18-year Review

The Pediatric Infectious Disease Journal
Ashley Howard, Jaime Fergie

Abstract

Murine typhus is a zoonotic infection caused by Rickettsia typhi that remains endemic in South Texas. In 2003, only 9 Texas counties reported murine typhus compared with 41 counties in 2013. A retrospective study of children discharged with a confirmed diagnosis of murine typhus from Driscoll Children's Hospital between January 1998 and September 2016. Two hundred thirteen children (113 female) 3 months through 19 years of age (mean, 11.2 ± 4.5 years) were identified. Cases occurred throughout the year. Children were admitted after a mean of 7.7 ± 5.3 days of fever. The most common symptoms were fever (100%), poor appetite (71.9%), malaise/fatigue (69.0%) and headache (67.6%). The most common laboratory abnormalities were elevated C-reactive protein, hypoalbuminemia, elevated erythrocyte sedimentation rate, elevated transaminases and elevated band count with normal total white blood cell count. Children defervesced in a mean of 31.87 ± 21.36 hours after initiation of doxycycline. Hospitalization lasted for a mean of 2.7 ± 1.8 days when children were administered doxycycline within 24 hours of admission compared with, 4.1 ± 1.8 days, P ≤ 0.0001 when started later. Eleven patients (5.1%) were admitted to the pediatric intensive c...Continue Reading

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Citations

Sep 29, 2018·Clinical Pediatrics·Dillon C Burks, Raymond Parlar-Chun
Jan 30, 2020·Clinical Pediatrics·Adam CohenMeghan McClure
Mar 4, 2020·Tropical Medicine and Infectious Disease·Gregory M Anstead
Aug 6, 2020·Tropical Medicine and Infectious Disease·M Kevin DixonGregory M Anstead
Apr 21, 2020·Emerging Infectious Diseases·Karla RuizLucas S Blanton
Jun 3, 2020·Pediatrics in Review·Margaret G Taylor, Debra L Palazzi
Dec 4, 2020·Journal of the Pediatric Infectious Diseases Society·Renuka ReesDeena Sutter
Feb 13, 2021·Research and Reports in Tropical Medicine·Maria A Caravedo MartinezLucas S Blanton
Jan 13, 2021·Hospital Pediatrics·Andrea DeanHannah C Neubauer
Apr 20, 2021·The Pediatric Infectious Disease Journal·Christopher SchmittLarry Yin

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