Abstract
VCAM-1 is an immunoglobulin (Ig) superfamily member expressed in endothelial cells that mediates adhesion to a variety of leukocytes in a VLA-4 dependent manner. In the mouse, two distinct forms of VCAM are produced. One form, VCAMTM, contains seven Ig domains followed by a single transmembrane region and a short cytoplasmic domain. A second form, VCAMGPI, which is preferentially induced by cytokines and LPS, contains only the first three Ig domains and is attached to the cell surface via a glycosylphosphafidylinositol (GPI) anchor. Both vascular and nonvascular expression of VCAM have been reported in a variety of normal and pathological settings. One possible role for the two VCAM isoforms is to allow for the targeted localization of VCAM to specific cell surface domains of polarized cells. This may be particularly relevant since VCAM is known to be expressed by two different polarized cell types, namely endothelial cells and kidney epithelial cells. In this study, MDCK cells permanently expressing either VCAMTM or VCAMGPI were established and used to examine the targeting of VCAM proteins to different polarized surface domains. VCAMTM was primarily located on the basolateral surface while VCAMGPI was located on the apical su...Continue Reading
References
Feb 28, 1992·Biochemical and Biophysical Research Communications·C HessionR Lobb
Jun 26, 1992·Cell·G D RosenD C Dean
Jan 1, 1992·Annual Review of Cell Biology·E Rodriguez-Boulan, S K Powell
May 1, 1992·The Journal of Cell Biology·C ZurzoloL Nitsch
Oct 11, 1990·Nucleic Acids Research·T PolteT V Gopal
Jun 11, 1991·The Journal of Experimental Medicine·B S BochnerR P Schleimer
Aug 1, 1991·The Journal of Cell Biology·K MiyakeP W Kincade
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N K Damle, A Aruffo
Jun 1, 1991·DNA and Cell Biology·T PolteT V Gopal
Sep 11, 1991·Proceedings of the National Academy of Sciences of the United States of America·M I CybulskyT Collins
Nov 15, 1991·Science·I StefanováH Stockinger
Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D SeronD O Haskard
Sep 5, 1991·Nature·S K PowellE Rodriguez-Boulan
Feb 25, 1991·Science·M I Cybulsky, M A Gimbrone
Feb 23, 1990·Cell·M GriecoG Vecchio
Nov 1, 1989·The Journal of Cell Biology·M P LisantiE Rodriguez-Boulan
Dec 22, 1989·Cell·L OsbornR Lobb
Mar 1, 1989·The Journal of Membrane Biology·M SargiacomoE Rodriguez-Boulan
Apr 1, 1994·Cell Adhesion and Communication·A M SheppardD C Dean
Jan 1, 1993·The Journal of Experimental Medicine·J L BaronC A Janeway
Jun 1, 1993·The Journal of Cell Biology·C ZurzoloE Rodriguez-Boulan
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R W TerryM A Labow
Sep 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K S SturmR A Pedersen
Apr 23, 1993·Science·C Zurzolo, E Rodriguez-Boulan
Citations
May 4, 1999·The Journal of Experimental Medicine·C Berlin-RufenachN Hogg
Aug 28, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Makiko TajimaYutaka Hata
Sep 21, 2006·The Journal of Biological Chemistry·Hee-Jung ByunHansoo Lee
Jan 22, 2020·Glia·Jessica L WilliamsRobyn S Klein