Mus cervicolor murine leukemia virus isolate M813 belongs to a unique receptor interference group

Journal of Virology
V PrassolovC Stocking

Abstract

Murine leukemia virus (MuLV) M813 was originally isolated from the Southeast Asian rodent Mus cervicolor. As with the ecotropic MuLVs derived from Mus musculus, its host range is limited to rodent cells. Earlier studies have mapped its receptor to chromosome 2, but it has not been established whether M813 shares a common receptor with any other MuLVs. In this study, we have performed interference assays with M813 and viruses from four interference groups of MuLV. The infection efficiency of M813 was not compromised in cells expressing any one of the other MuLVs, demonstrating that M813 must use a distinct receptor for cell entry. The entire M813 env coding region was molecularly cloned. Sequence analysis revealed high similarity with other MuLVs but with a unique receptor-binding domain. Substitution of M813 env sequences in Moloney MuLV resulted in a replication-competent virus with a host range and interference profile similar to those of the biological clone M813. M813 thus defines a novel receptor interference group of type C MuLVs.

References

Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M M LieberH G Coon
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M GrezW Ostertag
Jun 11, 1986·Nucleic Acids Research·G von Heijne
Sep 1, 1984·Molecular and Cellular Biology·J SorgeA E Cutting
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K HarbersR Jaenisch
Feb 1, 1995·Journal of Virology·J L BattiniJ M Heard
Dec 1, 1994·Journal of Virology·D G Miller, A D Miller
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·M P KavanaughA D Miller
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·C MünkC Stocking
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J A Levy
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·C S TailorD Kabat
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·J L BattiniA D Miller

❮ Previous
Next ❯

Citations

Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wenqin XuMaribeth V Eiden
Mar 10, 2016·Annual Review of Virology·Wenqin Xu, Maribeth V Eiden
Dec 15, 2017·Microbiology and Molecular Biology Reviews : MMBR·Alex D GreenwoodMaribeth V Eiden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.