Musashi1: a stem cell marker no longer in search of a function.

Cell Cycle
Robert I GlazerYuzhi Yin

Abstract

One of the earliest genes identified with stem and early progenitor cells is the RNA-binding protein, Musashi1 (Msi1). Through gene profiling of mammary epithelial cells transduced with Msi1, a unique autocrine signaling pathway was identified that activates both the Wnt and Notch pathways. This process was associated with increased secretion of the growth factor, PLF1 and inhibition of the secreted Wnt pathway inhibitor, DKK3. Identification of PLF1 as an effector of these pathways in the absence of the DKK3 tumor suppressor provides a new avenue for investigating differences between normal and malignant tissues, and potentially targeting tumor stem cells.

Citations

Jun 25, 2009·Journal of Molecular Histology·M Colitti, M Farinacci
Jan 31, 2013·Stem Cells and Development·Bizunesh M BorenaGerlinde R Van de Walle
Nov 13, 2012·Nucleic Acids Research·Stella TommasiAhmad Besaratinia
Oct 29, 2013·Pathology Oncology Research : POR·Meysam MoghbeliMohammad Reza Abbaszadegan
Nov 5, 2014·Leukemia & Lymphoma·Jaspal KaedaPhilipp le Coutre
Dec 9, 2015·Journal of Cell Communication and Signaling·Meysam MoghbeliMohammad Reza Abbaszadegan
Aug 10, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Fabio GaspariniLucia Manni
Oct 7, 2015·Frontiers in Neuroanatomy·Vladimir S MashanovJosé E García-Arrarás
May 1, 2010·Biomolecular Concepts·Kenichi HorisawaHiroshi Yanagawa
Feb 23, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Weiwei ShengJianping Zhou
Sep 17, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·George R NahasPranela Rameshwar
May 30, 2013·Oncotarget·Xiao-Yang WangRobert I Glazer
Apr 4, 2021·International Journal of Molecular Sciences·Miguel Padial-MolinaFrancisco O'Valle
Jun 28, 2014·Molecular Cytogenetics·Danika Di GiacomoCristina Mecucci

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