Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer

Cancer Medicine
Zhen ZongShuang Chen

Abstract

Aberrant expression of musashi2 (MSI-2) has been detected in several malignancies. However, its role in the progression of colorectal cancer (CRC) remains unknown. Our study was designed to investigate the expression and prognostic significance of MSI-2 protein in patients with colorectal cancer. The expression of MSI-2 was detected in 164 patients' colorectal cancer and control specimens by the tissue microarray technique and immunohistochemical staining. The correlations between MSI-2 expression and clinicopathological variables including overall survival were analyzed. The prognostic value of liver metastasis is evaluated by logistic regression and receiver operating characteristic (ROC) analysis. MSI-2 was highly expressed in 32.9% (54/164) of the colorectal cancer. Overexpression of MSI-2 was associated with depth of invasion, lymph node metastasis, distant metastasis, liver metastasis, Tumor Node Metastasis (TNM) clinical stage, and Carcinoembryonicantigen (CEA) level (P = 0.040, 0.014, <0.001, <0.001, 0.003, and 0.002, respectively). In the Cox multivariate test, MSI-2 overexpression, lymph node metastasis, and distant metastasis were found to be the independent prognostic factors (P = 0.027, 0.010, and 0.001, respective...Continue Reading

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Citations

Aug 12, 2020·Journal of Cellular and Molecular Medicine·Lei ZhouMing Dong
Aug 20, 2016·Clinical & Experimental Metastasis·Olga Golubnitschaja, Krishna Chander Sridhar
Sep 22, 2018·Current Colorectal Cancer Reports·Sarah F AndresAnil K Rustgi
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Aug 24, 2020·World Journal of Surgical Oncology·Xuehui FanGuozhong Li
Feb 2, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander E KudinovYanis Boumber
Mar 26, 2021·OncoTargets and Therapy·Jian SunMing Dong

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Methods Mentioned

BETA
RNASeq

Software Mentioned

SPSS

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