Abstract
Our previous investigations have revealed that cerebellar cholinergic innervation is involved in cardiovascular regulation. This study was performed to examine the effects of the muscarinic cholinergic receptor (mAChR) in the cerebellar cortex on blood pressure (BP) modulation in rats. Acetylcholine (ACh, 100mM), nonselective mAChR agonist (oxotremorine M; Oxo-M, 10, 30 and 100mM) and 100mM ACh mixed with nonselective mAChR antagonist atropine (1, 3 and 10mM) were microinjected into the cerebellar cortex of anesthetized rats. Mean arterial pressure (MAP), maximal decreased MAP (MDMAP), and reaction time (duration required for BP to return to basal values) were measured and analyzed. The results showed that Oxo-M dose-dependently decreased MAP, increased MDMAP, and prolonged reaction time, which displayed a homodromous effect of ACh-mediated blood depressor response; meanwhile, atropine concentration-dependently blocked the effect of ACh on the BP regulation. In conclusion, the present study showed for the first time that mAChRs in cerebellar cortex could modulate somatic BP by participation in ACh-mediated depressor response.
References
Apr 1, 1992·Neuroreport·A Gruart, J M Delgado-García
Mar 13, 1989·Neuroscience Letters·D BiesoldY Sato
Jun 15, 1988·The Journal of Comparative Neurology·A NeustadtA Rotter
Sep 1, 1968·International Journal of Neuropharmacology·I McCance, J W Phillis
Jan 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J K WamsleyM J Kuhar
Oct 1, 1952·The Journal of Comparative Neurology·O LARSELL
Mar 9, 2004·Brain Research. Brain Research Reviews·Nicolas SchweighoferShinya Kuroda
Jun 4, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juan de Dios Navarro-LópezJavier Yajeya
Jan 26, 2005·The Japanese Journal of Physiology·Naoko Nisimaru
Sep 10, 2005·The Journal of Physiology·Derek S KimmerlyJ Kevin Shoemaker
May 13, 2006·Journal of Applied Physiology·D M RectorR M Harper
Jan 6, 2007·Circulation Research·James R PadleyAnn K Goodchild
Aug 25, 2007·Brain Structure & Function·K W S Ashwell, G Paxinos
Jul 19, 2008·Neuro-Signals·Hideaki OgasawaraMitsuo Kawato
Apr 30, 2009·Journal of Hypertension·Natasha N KumarAnn K Goodchild
Dec 3, 2010·Brain Research·Milena Vieira DeolindoFernando Morgan Aguiar Corrêa
Dec 7, 2010·The Cerebellum·Asli Demirtas-TatlidedeJeremy D Schmahmann
Mar 1, 2011·Brain Research·Ali Nasimi, Masoumeh Hatam
Jun 14, 2013·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Tatsuya Haga
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lorenzo Rinaldo, Christian Hansel
Jul 3, 2013·Neuroscience Letters·Mohammad Naser ShafeiMahdi Hasanzade Daloee
Aug 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Naoko NisimaruMasao Ito
Nov 12, 2013·Behavioural Brain Research·Wei-Ning ZhangJoram Feldon
Jun 7, 2014·Nature Reviews. Drug Discovery·Andrew C KruseJürgen Wess
Aug 26, 2014·Journal of Acupuncture and Meridian Studies·Sae Uchida
Feb 11, 2015·Experimental Gerontology·Qingfeng ZhuTianmiao Hua
Citations
Nov 4, 2015·Neurochemical Research·Changzheng ZhangLiefeng Zhang
Aug 26, 2016·Reviews in the Neurosciences·Changzheng ZhangTifei Yuan
Oct 16, 2018·Neuroscience Bulletin·Yu DengYang-Kai Wang
Jan 29, 2021·World Journal of Emergency Medicine·Ning DongJi-Hong Xing
Oct 4, 2017·European Journal of Pharmacology·Esmaeal TamaddonfardFatmeh Delkhosh-Kasmaie