Muscarinic acetylcholine receptor in cerebellar cortex participates in acetylcholine-mediated blood depressor response in rats

Neuroscience Letters
Peiling ZhouTianmiao Hua

Abstract

Our previous investigations have revealed that cerebellar cholinergic innervation is involved in cardiovascular regulation. This study was performed to examine the effects of the muscarinic cholinergic receptor (mAChR) in the cerebellar cortex on blood pressure (BP) modulation in rats. Acetylcholine (ACh, 100mM), nonselective mAChR agonist (oxotremorine M; Oxo-M, 10, 30 and 100mM) and 100mM ACh mixed with nonselective mAChR antagonist atropine (1, 3 and 10mM) were microinjected into the cerebellar cortex of anesthetized rats. Mean arterial pressure (MAP), maximal decreased MAP (MDMAP), and reaction time (duration required for BP to return to basal values) were measured and analyzed. The results showed that Oxo-M dose-dependently decreased MAP, increased MDMAP, and prolonged reaction time, which displayed a homodromous effect of ACh-mediated blood depressor response; meanwhile, atropine concentration-dependently blocked the effect of ACh on the BP regulation. In conclusion, the present study showed for the first time that mAChRs in cerebellar cortex could modulate somatic BP by participation in ACh-mediated depressor response.

References

Sep 1, 1968·International Journal of Neuropharmacology·I McCance, J W Phillis
Jan 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J K WamsleyM J Kuhar
Mar 9, 2004·Brain Research. Brain Research Reviews·Nicolas SchweighoferShinya Kuroda
Jun 4, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juan de Dios Navarro-LópezJavier Yajeya
Jan 26, 2005·The Japanese Journal of Physiology·Naoko Nisimaru
May 13, 2006·Journal of Applied Physiology·D M RectorR M Harper
Jul 19, 2008·Neuro-Signals·Hideaki OgasawaraMitsuo Kawato
Dec 3, 2010·Brain Research·Milena Vieira DeolindoFernando Morgan Aguiar Corrêa
Dec 7, 2010·The Cerebellum·Asli Demirtas-TatlidedeJeremy D Schmahmann
Jun 14, 2013·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Tatsuya Haga
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lorenzo Rinaldo, Christian Hansel
Jul 3, 2013·Neuroscience Letters·Mohammad Naser ShafeiMahdi Hasanzade Daloee
Aug 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Naoko NisimaruMasao Ito
Jun 7, 2014·Nature Reviews. Drug Discovery·Andrew C KruseJürgen Wess
Aug 26, 2014·Journal of Acupuncture and Meridian Studies·Sae Uchida

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