Muscarinic agonists modulate calcium-dependent outward currents in an identified insect motoneurone

Brain Research
J A David, R M Pitman

Abstract

The soma membrane of the fast coxal depressor (Df) motoneurone of the cockroach, Periplaneta americana possesses a population of acetylcholine receptors which respond to both nicotinic and muscarinic ligands. Activation of these 'mixed' acetylcholine receptors by McN-A-343 or oxotremorine results in the generation of an inward current at potentials positive to - 40 mV. A large proportion of the outward current induced by membrane depolarization in Df somata is due to a calcium-activated potassium conductance (IKCa) which shows a characteristic N-shape voltage-dependence. This N-shape of the membrane current-voltage relationship is suppressed by McN-A-343 or oxotremorine indicating that the agonist-induced inward current is due to a reduction in IKCa.

References

Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·W D Nightingale, R M Pitman
May 1, 1971·The Journal of Physiology·K KrnjevićL Renaud
Oct 28, 1982·Brain Research·J V Halliwell, P R Adams
Jun 1, 1983·Cellular and Molecular Neurobiology·J M ffrench-MullenD O Carpenter

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Citations

Feb 13, 2001·Progress in Neurobiology·C M Comer, R M Robertson
Jan 26, 1996·Neuroscience Letters·J A David, R M Pitman
Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·C L DevlinN Zitomer

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