PMID: 6167327Jul 27, 1981Paper

Muscarinic cholinergic receptors flow in the sciatic nerve

Brain Research
J K WamsleyM J Kuhar

Abstract

Muscarinic cholinergic receptors build up on the proximal side of a ligature placed on the rat sciatic and vagus nerves. These receptors appear to be flowing down the axons of at least a portion of the nerve fibers present in sciatic and vagus nerves. Most of the anterograde flowing muscarinic binding sites are displaceable with 10(-4) M carbachol indicating that many are high affinity agonist binding sites. These receptors can also be localized in the ganglionic nerve cell bodies in the dorsal root ganglia which contribute fibers to the sciatic nerve. We hypothesize that muscarinic cholinergic receptors are synthesized in the ganglion cell bodies and transported distally in sensory nerve axons in the sciatic nerve.

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Citations

Jan 1, 1992·Molecular Neurobiology·J K Wamsley
Aug 12, 1985·Brain Research·W R MillingtonM J Kuhar
Dec 24, 1982·European Journal of Pharmacology·J K Wamsley
Jan 1, 1984·Neurochemistry International·K Gulya, P Kása
Jan 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·M J Majchrzak, S C Dilsaver
Jul 1, 1985·Brain Research Bulletin·D B HooverT E DePorter
Jan 1, 1983·Hearing Research·W M JamesW L Klein
Jun 1, 1997·Brain Research. Brain Research Reviews·R E Coggeshall, S M Carlton
Oct 24, 2000·Brain Research. Molecular Brain Research·A M TataG Mengod
Aug 28, 1999·Neuroscience Letters·R HaberbergerW Kummer
Jan 1, 1990·Annals of the New York Academy of Sciences·P M Laduron, M N Castel
Dec 1, 1989·Journal of the Autonomic Nervous System·J P TernauxP Portalier
May 2, 2001·Journal of Clinical Anesthesia·M NakayamaA Namiki
Nov 1, 1983·Pharmacology, Biochemistry, and Behavior·D A WeldonK J Nicklaus
May 1, 1982·Brain Research Bulletin·A R Granata, G N Woodruff
Jun 1, 1997·Molecular Neurobiology·F ZafraC Giménez
Jan 1, 1987·Molecular Neurobiology·R S DumanJ F Tallman
Jun 19, 2008·Pharmacology & Therapeutics·Neil M Nathanson
Jun 8, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M HübschM Raab
Sep 17, 1984·Brain Research·N J Buckley, G Burnstock
Jul 1, 1984·Journal of Neurochemistry·M R Whipple, D G Drescher

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