Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig

British Journal of Pharmacology
A D Fryer, J Maclagan

Abstract

In anaesthetized guinea-pigs, gallamine produced a dose-related potentiation of the bronchoconstriction induced by electrical stimulation of the cervical vagus nerves; (+)-tubocurarine and suxamethonium lacked this effect. The bronchoconstriction produced by intravenous injection of acetylcholine or histamine, however, was not potentiated by gallamine. Vagally-induced bradycardia was abolished by gallamine, confirming antagonism of the effect of acetylcholine on muscarinic receptors in the heart. The muscarinic receptor agonist pilocarpine, had the opposite effect to gallamine in the lung as it inhibited vagally-mediated bronchoconstriction. Pretreatment of guinea-pigs with either guanethidine or propranolol did not affect the gallamine-induced potentiation of vagally-mediated bronchoconstriction. The potentiating effect of gallamine in the lung can be explained by blockade of inhibitory, muscarinic receptors located in the parasympathetic nerves supplying the lungs.

References

Dec 14, 1999·Phytotherapy Research : PTR·D M Wynter-AdamsM E West
Apr 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·A D Fryer, J Maclagan
Aug 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·G D'AgostinoH Kilbinger
Jul 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·K RackéI Wessler
Jan 1, 1992·Veterinary Research Communications·M YuF J Derksen
Mar 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·O ShibataK Sumikawa
Mar 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S B BackmanC Polosa
May 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G C Moudgil
Mar 17, 2007·Cellular and Molecular Life Sciences : CMLS·S G Trivedi, C M Lloyd
Oct 10, 2009·Current Allergy and Asthma Reports·Kirsten C VerheinD B Jacoby
Apr 12, 1989·European Journal of Pharmacology·C OminiL Daffonchio
May 19, 1989·European Journal of Pharmacology·J C Mak, P J Barnes
Jan 3, 1990·European Journal of Pharmacology·D F Biggs, R C Ladenius
Feb 14, 1991·European Journal of Pharmacology·Z J Yang, D F Biggs
Nov 12, 1991·European Journal of Pharmacology·S ItabashiT Takishima
Jan 21, 1992·European Journal of Pharmacology·C R Killingsworth, N E Robinson
Nov 2, 1993·European Journal of Pharmacology·D McCaig, S De Jonckheere
Nov 14, 1994·European Journal of Pharmacology·R E HowellK D Laemont
Jan 1, 1990·Molecular Aspects of Medicine·P J Barnes
Jan 1, 1987·Pharmacology & Therapeutics·R G Andersson, N Grundström
Jan 1, 1988·Pharmacology & Therapeutics·F Mitchelson
Jun 1, 1993·Pharmacology & Therapeutics·M P Caulfield
Feb 1, 1993·Pharmacology & Therapeutics·Y D Pendry
Jun 25, 1995·Journal of the Autonomic Nervous System·S MatsumotoT Shimizu
Nov 1, 1988·Trends in Pharmacological Sciences·P J BarnesJ Maclagan
Jul 1, 1995·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·Y Chiba, M Misawa
Jan 1, 1993·Journal of Physiology, Paris·H KilbingerR S von Bardeleben
Mar 10, 2001·Respiration Physiology·B J Canning, A Fischer
Apr 2, 2003·Pharmacology & Therapeutics·Fiona R Coulson, A D Fryer
Mar 27, 2003·Pulmonary Pharmacology & Therapeutics·P J KinghamW Graham McLean
Nov 20, 2001·Current Opinion in Pharmacology·A M LeeA D Fryer
Jun 18, 2003·Current Opinion in Pharmacology·Darryl AdamkoRedwan Moqbel
Aug 1, 1997·British Journal of Pharmacology·K E BelmonteA D Fryer

Citations

Jul 1, 1979·British Journal of Pharmacology·J Maclagan, U M Ney
Oct 1, 1972·The Journal of Pharmacy and Pharmacology·W C Bowman, S N Webb
Oct 1, 1968·British Journal of Anaesthesia·B R Kennedy, J V Farman
Feb 1, 1980·British Journal of Pharmacology·P Fosbraey, E S Johnson
Nov 1, 1982·The Journal of Physiology·J P GallagherP Shinnick-Gallagher
Nov 1, 1983·Clinical and Experimental Pharmacology & Physiology·E Leung, F Mitchelson
Nov 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·H Kilbinger, I Wessler
Oct 1, 1951·Annals of the New York Academy of Sciences·W F RIKER, W C WESCOE

Related Concepts

Histamine Measurement
Gallamine
Nervousness
PIGS
Parasympathetic Nerve Structure
Lung
Bradycardia
Cavia
Flaxedil
Intravenous Injections

Related Feeds

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.