Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons

Journal of Neurochemistry
Yun ZhuHui-Lin Pan

Abstract

Neurons in the vestibular nuclei have a vital function in balance maintenance, gaze stabilization, and posture. Although muscarinic acetylcholine receptors (mAChRs) are expressed and involved in regulating vestibular function, it remains unclear how individual mAChR subtypes regulate vestibular neuronal activity. In this study, we determined which specific subtypes of mAChRs control synaptic input and excitability of medial vestibular nucleus (MVN) neurons that project to the cerebellum. Cerebellum-projecting MVN neurons were labeled by a fluorescent retrograde tracer and then identified in rat brainstem slices. Quantitative PCR analysis suggested that M2 and M3 were the possible major mAChR subtypes expressed in the MVN. The mAChR agonist oxotremorine-M significantly reduced the amplitude of glutamatergic excitatory post-synaptic currents evoked by stimulation of vestibular primary afferents, and this effect was abolished by the M2-preferring antagonist AF-DX 116. However, oxotremorine-M had no effect on GABA-mediated spontaneous inhibitory post-synaptic currents of labeled MVN neurons. Furthermore, oxotremorine-M significantly increased the firing activity of labeled MVN neurons, and this effect was blocked by the M3-preferri...Continue Reading

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Citations

Mar 15, 2018·Journal of Neurophysiology·Shahaf Weiss, Dori Derdikman
Sep 12, 2018·Journal of Neurochemistry·Li WangHui-Lin Pan
Mar 27, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Brian J LithgowPaul B Fitzgerald
Aug 8, 2018·European Archives of Psychiatry and Clinical Neuroscience·Brian J LithgowPaul B Fitzgerald
Nov 30, 2018·Frontiers in Neurology·Erwin IdouxMathieu Beraneck

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