Muscarinic receptors in cell lines from ovarian carcinoma: negative correlation with survival of patients

Gynecologic Oncology
Matthias OppitzU Drews

Abstract

Tumor cells are similar in many respects to embryonic cells, indicating that embryonic genes are reactivated during malignant growth. In previous studies, we observed muscarinic acetylcholine receptors, which are expressed in embryonic cells during morphogenesis and are also found in human melanomas and melanoma cell lines. We determined the presence of muscarinic receptors in a collection of ovarian tumor cell lines for which clinical data were available. Muscarinic receptor status of 39 cell lines derived from 34 patients was determined by Western blotting. Twenty-three cell lines were receptor positive, and 16, receptor negative. Kaplan-Meier analysis of receptor status of the tumor cell lines and survival time of patients from which the cell lines were established showed that expression of muscarinic receptors was associated with a reduced probability (P = 0.025) of survival: This is within the range of other established prognostic factors reported in the literature. A large percentage of ovarian tumor cell lines express muscarinic receptors. Muscarinic receptor expression is an embryonic trait and is correlated with reduced survival of patients. The results from this study provide further evidence of the involvement of mus...Continue Reading

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Citations

Jan 24, 2012·Acta Pharmacologica Sinica·Rosamaria Lappano, Marcello Maggiolini
Nov 28, 2008·American Journal of Physiology. Cell Physiology·Nirish ShahJean-Pierre Raufman
Aug 29, 2009·Cell Communication and Signaling : CCS·Rodrigo R Resende, Avishek Adhikari
Jul 11, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun WuJianqun Ma
Oct 13, 2015·Neurochemistry International·Maria Di BariAda Maria Tata
Aug 2, 2006·Autonomic & Autacoid Pharmacology·R M Eglen
Mar 16, 2013·Journal of Cellular and Molecular Medicine·Michela FerrettiAda Maria Tata
Dec 9, 2014·Cancer Biology & Therapy·Luca PaciniAntonella Calogero
Apr 22, 2008·Journal of Cutaneous Pathology·Matthias OppitzUlrich Drews
Oct 31, 2020·Cancers·Anna Maria Lucianò, Ada Maria Tata
Mar 27, 2021·Seminars in Cancer Biology·Gloria M Calaf
Nov 14, 2020·International Journal of Molecular Sciences·Anna Maria LucianòAda Maria Tata
Mar 12, 2003·Life Sciences·Carol L Williams

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