PMID: 2125713Oct 16, 1990Paper

Muscarinic receptors mediate the release of arachidonic acid from spinal cord and hippocampal neurons in primary culture

Neuroscience Letters
R Y KantermanC C Felder

Abstract

Muscarinic receptors are involved in CNS neurotransmissions and have been shown to transduce their message by modulating cAMP, calcium, inositol phosphates, and more recently, by liberating arachidonic acid via phospholipase A1. We have previously shown that the alpha 1-adrenergic and 5-HT2 serotonergic neurotransmitter receptors cause the release of arachidonic acid from spinal cord and hippocampal neurons, respectively, in primary culture. In this study, we demonstrated a muscarinic receptor-mediated release of arachidonic acid in these two neural segments which occurred independent of phosphatidylinositol-specific phospholipase C. This release of arachidonic acid was neuronal (not glial) in origin and exhibited M1 muscarinic receptor pharmacology.

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R L BellP W Majerus
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B R ConklinJ Axelrod

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Citations

Jan 1, 1992·Progress in Neurobiology·M Inoue, M Yoshii
Aug 1, 1995·Progress in Neurobiology·H Katsuki, S Okuda
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C C FelderE C Kohn
Jan 1, 1997·Annual Review of Physiology·N V Marrion
Dec 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Liwang Liu, Ann R Rittenhouse
Feb 1, 2003·Journal of Neurochemistry·Rhonda Jo PearlmanRobert J Vandenberg
Sep 24, 2008·Handbook of Clinical Neurology·Richard B Mailman, Xuemei Huang
Dec 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Chunyu ZengPedro A Jose
Apr 25, 2008·Critical Reviews in Toxicology·Edward J Calabrese
Apr 5, 2001·American Journal of Physiology. Cell Physiology·L LiuA R Rittenhouse

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