PMID: 37300May 1, 1979

Muscimol and related GABA receptor agonists: the potency of GABAergic drugs in vivo determined after intranigral injection

The Journal of Pharmacy and Pharmacology
J ArntP Krogsgaard-Larsen


Contralateral turning behaviour following unilateral intranigral injection of a large series of GABA analogues was investigated. The results indicated that the turning behaviour was induced stereospecifically and was selectively antagonized by the GABA antagonist bicuculline methochloride. The comparative potencies of a series of GABA agonists related to muscimol in general corresponded well to the affinity for 3H-GABA receptor sites and to the depressant action on single neurons using microelectrophoretic administration. However, the GABA agonists trans-aminocrotonic acid and 3-aminopropanesulphonic acid were much weaker than expected from in vitro studies. The GABA-uptake inhibitors nipecotic acid and guvacine showed only weak and short-lasting effects. The GABA-transaminase inhibitor gamma-acetylenic GABA showed delayed effects compared with the agonists which acted immediately. It is proposed that this behavioural effect may be a sensitive and quantitative method for evaluation of GABA agonists in vivo.


Aug 11, 1981·Molecular and Cellular Biochemistry·P Krogsgaard-Larsen, E Falch
Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·J Arnt, J Scheel-Krüger
Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·S WolfarthK H Sontag
Oct 22, 1982·Pharmaceutisch Weekblad. Scientific Edition·A V ChristensenP Krogsgaard-Larsen
Aug 15, 1983·Experientia·F V DeFeudis
Oct 15, 1979·European Journal of Pharmacology·M Karobath, M Lippitsch
Jul 11, 1980·European Journal of Pharmacology·B L WaszczakJ R Walters
Feb 19, 1981·European Journal of Pharmacology·I C Kilpatrick, M S Starr
May 1, 1982·Pharmacology, Biochemistry, and Behavior·J T McDevitt, L M Yunger
Jan 1, 1980·Neuroscience·C J Pycock
Jul 13, 2002·Bioorganic & Medicinal Chemistry Letters·Paul R CarlierJeffrey R Bloomquist
Feb 11, 2004·Experimental Neurology·Aristea S Galanopoulou, Solomon L Moshé
Oct 1, 1980·Neurochemical Research·F V DeFeudis
Jan 1, 1980·Archiv für Psychiatrie und Nervenkrankheiten·H M EmrichA Windorfer
Mar 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·P Worms, K G Lloyd
Jan 1, 1980·Psychopharmacology·D E CaseyE Christensson
May 7, 1979·Life Sciences·S J Enna, A Maggi
Mar 1, 1980·Journal of Neurochemistry·P Krogsgaard-LarsenD Lodge


Apr 1, 1976·The Journal of Pharmacy and Pharmacology·A Dray, D W Straughan
Mar 1, 1977·The Journal of Pharmacy and Pharmacology·T A James, M S Starr
Jul 7, 1977·Nature·P Krogsgaard-LarsenD R Curtis
Jan 1, 1975·Journal of Neurochemistry·G A JohnstonB Twitchin
Jun 15, 1977·European Journal of Pharmacology·C OberlanderJ R Boissier
May 16, 1975·Brain Research·D TarsyC D Marsden
Dec 1, 1975·Journal of Neurochemistry·P Krogsgaard-LarsenR M McCulloch
Dec 18, 1975·Nature·G A JohnstonA L Stephanson
Jan 1, 1976·Experimental Neurology·J S MendezK E Dahl
Oct 8, 1971·Brain Research·D R CurtisH McLennan
Feb 1, 1973·Journal of Neurochemistry·P M Beart, G A Johnston
Oct 1, 1964·British Journal of Pharmacology and Chemotherapy·J M CRAWFORD, D R Curtis

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