PMID: 11337203May 5, 2001Paper

Muscle activity-resistant acetylcholine receptor accumulation is induced in places of former motor endplates in ectopically innervated regenerating rat muscles

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
R GaspersicJ Sketelj

Abstract

Expression of acetylcholine receptors (AChRs) in the extrajunctional muscle regions, but not in the neuromuscular junctions, is repressed by propagated electric activity in muscle fibers. During regeneration, subsynaptic-like specializations accumulating AChRs are induced in new myotubes by agrin attached to the synaptic basal lamina at the places of former motor endplates even in the absence of innervation. We examined whether AChRs still accumulated at these places when the regenerating muscles were ectopically innervated and the former synaptic places became extrajunctional. Rat soleus muscles were injured by bupivacaine and ischemia to produce complete myofiber degeneration. The soleus muscle nerve was permanently severed and the muscle was ectopically innervated by the peroneal nerve a few millimeters away from the former junctional region. After 4 weeks of regeneration, the muscles contracted upon nerve stimulation, showed little atrophy and the cross-section areas of their fibers were completely above the range in non-innervated regenerating muscles, indicating successful innervation. Subsynaptic-like specializations in the former junctional region still accumulated AChRs (and acetylcholinesterase) although no motor nerv...Continue Reading

References

Nov 23, 1978·Nature·B Sakmann, H R Brenner
Nov 1, 1975·The Journal of Physiology·T Lomo, R H Westgaard
Jul 1, 1991·The Journal of Cell Biology·V WitzemannB Sakmann
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·U J McMahan
Mar 1, 1986·Journal of Neurochemistry·M VitadelloS Schiaffino
Jan 1, 1987·Annual Review of Neuroscience·S M Schuetze, L W Role
Apr 1, 1989·The Journal of Cell Biology·H J Tsay, J Schmidt
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A Klarsfeld, J P Changeux
Sep 1, 1985·The Journal of Cell Biology·L Anglister, U J McMahan
Jan 1, 1985·Journal of Neuroscience Research·J Sketelj, M Brzin
Jul 1, 1984·The Journal of Cell Biology·J P MerlieJ R Sanes
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·S KoikeJ P Changeux
Jan 1, 1995·Annual Review of Neuroscience·M A Bowe, J R Fallon
Apr 1, 1995·Physiological Reviews·A Duclert, J P Changeux
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L BessereauJ P Changeux
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G JonesH R Brenner
Jan 1, 1997·Annual Review of Neuroscience·G D Fischbach, K M Rosen
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G JonesH R Brenner
Apr 15, 1999·Annual Review of Neuroscience·J R Sanes, J W Lichtman
Sep 22, 1999·European Journal of Biochemistry·W Hoch

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Citations

Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·J B Harris
May 5, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R Schliebs
Dec 5, 2012·Journal of Manipulative and Physiological Therapeutics·Barbara CagnieLieven Danneels
Dec 8, 2004·The European Journal of Neuroscience·Marko JevsekZoran Grubic
Aug 29, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarina MisSergej Pirkmajer
Jan 17, 2021·Life·Eva María Martínez-JiménezRicardo Becerro-de-Bengoa-Vallejo

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