Muscle adaptations to hindlimb suspension in mature and old Fischer 344 rats

Journal of Applied Physiology
C S StumpE J Henriksen

Abstract

We examined skeletal and cardiac muscle responses of mature (8 mo) and old (23 mo) male Fischer 344 rats to 14 days of hindlimb suspension. Hexokinase (HK) and citrate synthase (CS) activities and GLUT-4 glucose transporter protein level, which are coregulated in many instances of altered neuromuscular activity, were analyzed in soleus (Sol), plantaris (PI), tibialis anterior (TA), extensor digitorum longus (EDL), and left ventricle. Protein content was significantly (P < 0.05) lower in all four hindlimb muscles after suspension compared with controls in both mature (21-44%) and old (17-43%) rats. Old rats exhibited significantly lower CS activities than mature rats for the Sol, Pl, and TA. HK activities were significantly lower in the old rats for the Pl (19%) and TA (33%), and GLUT-4 levels were lower in the old rats for the TA (38%) and EDL (24%) compared with the mature rats. Old age was also associated with a decrease in CS activity (12%) and an increase in HK activity (14%) in cardiac muscle. CS activities were lower in the Sol (20%) and EDL (18%) muscles from mature suspended rats and in the Sol (25%), Pl (27%), and EDL (25%) muscles from old suspended rats compared with corresponding controls. However, suspension was as...Continue Reading

References

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Citations

Feb 17, 2001·Muscle & Nerve·K D Chen, S E Alway
Apr 5, 2002·Biological Research for Nursing·B E OjalaL V Thompson
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Judy M Muller-DelpMichael D Delp
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·J KernerC L Hoppel
Dec 19, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chiao-Nan Joyce ChenLaDora V Thompson
May 23, 2003·Korean Journal of Biological Sciences·J S ShinI H Choi
Aug 30, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Parco M SiuStephen E Alway
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Judy Muller-DelpMichael D Delp
Dec 1, 2006·American Journal of Physiology. Cell Physiology·Emidio E PistilliStephen E Alway
Dec 11, 2007·Scandinavian Journal of Medicine & Science in Sports·A CornachioneA C Mattiello-Sverzut
Oct 9, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James G MackrellGregory D Cartee
Jan 10, 2018·Experimental Physiology·J Matthew KuczmarskiJohn M Lawler
May 4, 2004·Journal of Applied Physiology·Jason C GalleglyEsther E Dupont-Versteegden
Aug 31, 2001·Medicine and Science in Sports and Exercise·M R DeschenesW C Chandler
Dec 24, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·T Peter Stein, Charles E Wade
Mar 29, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Emidio E PistilliStephen E Alway
May 28, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Parco M SiuStephen E Alway
Dec 24, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D P WilkersonA C Shore
Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Esther E Dupont-VersteegdenCharlotte A Peterson
Feb 27, 2003·Aging Clinical and Experimental Research·Jon J Groskreutz, LaDora V Thompson
Jul 1, 2005·The Journal of Nutrition·T P Stein, C E Wade
Jan 5, 2005·The Journal of Nutritional Biochemistry·T Peter SteinCharles E Wade

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