Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism.

The Journal of Biological Chemistry
A O GramoliniBernard J Jasmin

Abstract

Duchenne muscular dystrophy is a prevalent X-linked neuromuscular disease for which there is currently no cure. Recently, it was demonstrated in a transgenic mouse model that utrophin could functionally compensate for the lack of dystrophin and alleviate the muscle pathology (Tinsley, J. M., Potter, A. C., Phelps, S. R., Fisher, R., Trickett, J. I., and Davies, K. E. (1996) Nature 384, 349-353). In this context, it thus becomes essential to determine the cellular and molecular mechanisms presiding over utrophin expression in attempts to overexpress the endogenous gene product throughout skeletal muscle fibers. In a recent study, we showed that the nerve exerts a profound influence on utrophin gene expression and postulated that nerve-derived trophic factors mediate the local transcriptional activation of the utrophin gene within nuclei located in the postsynaptic sarcoplasm (Gramolini, A. O., Dennis, C. L., Tinsley, J. M., Robertson, G. S., Davies, K. E, Cartaud, J., and Jasmin, B. J. (1997) J. Biol. Chem. 272, 8117-8120). In the present study, we have therefore focused on the effect of agrin on utrophin expression in cultured C2 myotubes. In response to Torpedo-, muscle-, or nerve-derived agrin, we observed a significant 2-fol...Continue Reading

References

Dec 10, 1992·Nature·J M TinsleyD R Love
Jan 1, 1991·Neuromuscular Disorders : NMD·A E Emery
Jan 1, 1991·Neuromuscular Disorders : NMD·T S KhuranaL M Kunkel
Nov 14, 1991·Biochemical and Biophysical Research Communications·M TakemitsuH Sugita
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D R LoveK E Davies
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A DuclertJ P Changeux
Dec 1, 1982·The Journal of Cell Biology·D BaderD A Fischman
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·S KoikeJ P Changeux
Nov 6, 1995·FEBS Letters·B J JasminJ Cartaud
Apr 1, 1995·Physiological Reviews·A Duclert, J P Changeux
May 1, 1995·The Journal of Cell Biology·M W CohenS Carbonetto
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·J M TinsleyK E Davies
Nov 1, 1993·Human Molecular Genetics·M PearceK E Davies
Jan 1, 1993·Journal of the Neurological Sciences·J ZhaoM Miyatake
Mar 1, 1993·Journal of Neuropathology and Experimental Neurology·G KarpatiP Holland
May 1, 1996·Nucleic Acids Research·C L DennisK E Davies
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G JonesH R Brenner
May 17, 1996·Cell·D J GlassG D Yancopoulos
Jan 1, 1996·Brain Pathology·H M Sadoulet-Puccio, L M Kunkel
Jan 1, 1996·Brain Pathology·D J BlakeK E Davies
Mar 28, 1997·The Journal of Biological Chemistry·A O GramoliniB J Jasmin
May 5, 1997·The Journal of Cell Biology·A J DenzerM A Ruegg
Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A O Gramolini, B J Jasmin

❮ Previous
Next ❯

Citations

Apr 11, 2000·Microscopy Research and Technique·A O GramoliniB J Jasmin
Mar 20, 2002·Current Neurology and Neuroscience Reports·D M Escolar, C G Scacheri
Mar 20, 2002·Current Neurology and Neuroscience Reports·P R Clemens, F J Duncan
Nov 20, 2002·Biochemical and Biophysical Research Communications·Mau Sun ChangYuh Cheng Yang
Feb 17, 2000·Brain Research. Developmental Brain Research·S Lin, J M Burgunder
Oct 6, 2000·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·E ChaubourtS de La Porte
Jan 5, 2002·Journal of Physiology, Paris·Emmanuel ChaubourtSabine De La Porte
Sep 11, 2002·Neuromuscular Disorders : NMD·Kelly J Perkins, Kay E Davies
Nov 21, 2001·Nature Reviews. Neuroscience·J R Sanes, J W Lichtman
Oct 4, 2003·Nature Reviews. Genetics·Judith C T van Deutekom, Gert-Jan B van Ommen
Sep 22, 1999·European Journal of Biochemistry·W Hoch
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alison R AmentaJustin R Fallon
Aug 14, 1999·Nucleic Acids Research·A O Gramolini, B J Jasmin
Nov 15, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Weining Bian, Nenad Bursac
Sep 10, 2002·Neuroreport·Martin A Smith, Lutz G W Hilgenberg
Apr 4, 2007·Genes & Development·Christoph HandschinBruce M Spiegelman
Apr 15, 1999·Annual Review of Neuroscience·J R Sanes, J W Lichtman
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·R Y ChanB J Jasmin
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Joe V ChakkalakalBernard J Jasmin
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·E A BurtonK E Davies
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A O GramoliniB J Jasmin
Nov 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anthony O GramoliniDavid H MacLennan
Nov 6, 2001·Journal of Neuroimmunology·S PoëaS Berrih-Aknin
May 21, 2003·The Journal of Cell Biology·Eric LacazetteHans Rudolf Brenner
Mar 12, 2013·Expert Opinion on Drug Discovery·Catherine Moorwood, Tejvir S Khurana
Mar 5, 2016·American Journal of Human Genetics·Kay E Davies
Jul 16, 2003·Journal of Neurochemistry·Guy BélangerBernard J Jasmin
Jun 3, 2004·Neuroscience Letters·Marianna RodovaMichael J Werle
Jan 31, 2006·Trends in Molecular Medicine·Pedro Miura, Bernard J Jasmin
Jan 31, 2002·Molecular and Cellular Neurosciences·Lutz G W HilgenbergMartin A Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.