Muscle blood flow response to contraction: influence of venous pressure

Journal of Applied Physiology
Zoran ValicPhilip S Clifford

Abstract

The skeletal muscle pump is thought to be at least partially responsible for the immediate muscle hyperemia seen with exercise. We hypothesized that increases in venous pressure within the muscle would enhance the effectiveness of the muscle pump and yield greater postcontraction hyperemia. In nine anesthetized beagle dogs, arterial inflow and venous outflow of a single hindlimb were measured with ultrasonic transit-time flow probes in response to 1-s tetanic contractions evoked by electrical stimulation of the sciatic nerve. Venous pressure in the hindlimb was manipulated by tilting the upright dogs to a 30 degrees angle in the head-up or head-down positions. The volume of venous blood expelled during contractions was 2.2 +/- 0.2, 1.6 +/- 0.2, and 1.4 +/- 0.2 ml with the head-up, horizontal, and head-down positions, respectively. Although altering hindlimb venous pressure influenced venous expulsion during contraction, the increase in arterial inflow was similar regardless of position. Moreover, the volume of blood expelled was a small fraction of the cumulative arterial volume after the contraction. These results suggest that the muscle pump is not a major contributor to the hyperemic response to skeletal muscle contraction.

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Citations

Jun 1, 2013·Journal of Biomechanical Engineering·Alper YamanCan A Yucesoy
Jul 15, 2006·The Journal of Physiological Sciences : JPS·Hironobu MoritaToshikazu Shiga
Jan 12, 2008·European Journal of Applied Physiology·Junichiro Yamauchi, Alan Hargens
Jul 23, 2005·Journal of Applied Physiology·Don Sheriff
Dec 22, 2005·European Journal of Applied Physiology·Leonardo F FerreiraThomas J Barstow
Feb 25, 2006·The Journal of Physiology·Philip S CliffordJeffrey L Jasperse
Apr 4, 2006·The Journal of Physiology·Leonardo F FerreiraDavid C Poole
Jul 4, 2015·Journal of Applied Physiology·Jeffrey L JaspersePhilip S Clifford
Apr 9, 2019·International Journal of Sports Physiology and Performance·Llion A RobertsVincent G Kelly
Mar 25, 2020·Orthopaedic Journal of Sports Medicine·Susanna AufwerberPaul W Ackermann
Aug 31, 2018·Frontiers in Physiology·Alessandro MessereSilvestro Roatta
Jul 28, 2021·Journal of Sport and Health Science·Shane F O'RiordanJames R Broatch

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