Muscle chemoreflex increases renal sympathetic nerve activity during exercise

Journal of Applied Physiology
K P O'HaganP S Clifford

Abstract

Activation of the muscle chemoreflex increases sympathetic drive to skeletal muscle in humans. This study investigated whether activation of the muscle chemoreflex augments the renal sympathetic nerve activity (RSNA) response to dynamic exercise in rabbits. The muscle chemoreflex was evoked by hindlimb ischemia during exercise on a motorized treadmill. Seven New Zealand White rabbits performed a nonischemic control protocol and a hindlimb ischemia protocol in which terminal aortic blood flow (Qta) was reduced to 51 +/- 2% of preocclusion Qta by partial aortic occlusion after 1.5 min of exercise. Mean arterial pressure (MAP), heart rate, RSNA and Qta increased in response to exercise and were similar between trials during the first 1.5 min of exercise. In the control trial, Qta, MAP, and RSNA were stable at an elevated level through an additional 3.5 min of exercise. Hindlimb ischemia produced a potent pressor response that plateaued after 2.5 min (delta + 17 +/- 4 mmHg, where delta designates change). RSNA began to increase after 1.5 min of ischemic exercise and was significantly elevated relative to preocclusion RSNA at 2.5 (delta + 25 +/- 9%) and 3.5 (delta + 47 +/- 12%) min of occlusion. These results suggest that the muscle...Continue Reading

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Citations

Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R L HammondD S O'Leary
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R A AugustyniakD S O'Leary
Jul 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Donal S O'LearyEric J Ansorge
Jan 21, 2000·Journal of Applied Physiology·T NishiyasuG W Mack
Jul 23, 2003·Journal of Applied Physiology·Filiz GündüzUmit Kemal Sentürk
Jun 12, 2009·American Journal of Physiology. Renal Physiology·Nathan T KuipersChester A Ray
Jul 30, 2020·Animals : an Open Access Journal From MDPI·Wilson M LozanoManuel Zarzoso
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·R A L DampneyT Tagawa
Apr 7, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rachel C DrewLawrence I Sinoway

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