Muscle contraction increases lactate transport while reducing sarcolemmal MCT4, but not MCT1

American Journal of Physiology. Endocrinology and Metabolism
Mio TonouchiArend Bonen

Abstract

Rates of lactate uptake into giant sarcolemmal vesicles were determined in vesicles collected from rat muscles at rest and immediately after 10 min of intense muscle contraction. This contraction period reduced muscle glycogen rapidly by 37-82% in all muscles examined (P < 0.05) except the soleus muscle (no change P > 0.05). At an external lactate concentration of 1 mM lactate, uptake into giant sarcolemmal vesicles was not altered (P > 0.05), whereas at an external lactate concentration of 20 mM, the rate of lactate uptake was increased by 64% (P < 0.05). Concomitantly, the plasma membrane content of monocarboxylate transporter (MCT)1 was reduced slightly (-10%, P < 0.05), and the plasma membrane content of MCT4 was reduced further (-25%, P < 0.05). In additional studies, the 10-min contraction period increased the plasma membrane GLUT4 (P < 0.05) while again reducing MCT4 (-20%, P < 0.05) but not MCT1 (P > 0.05). These studies have shown that intense muscle contraction can increase the initial rates of lactate uptake, but only when the external lactate concentrations are high (20 mM). We speculate that muscle contraction increases the intrinsic activity of the plasma membrane MCTs, because the increase in lactate uptake occur...Continue Reading

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Citations

Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Peter I WuElazer R Edelman
Sep 8, 2004·Biochemical and Biophysical Research Communications·Carley R BentonArend Bonen
May 7, 2005·Metabolism: Clinical and Experimental·Guillaume PyAndré-Xavier Bigard
Aug 5, 2004·American Journal of Physiology. Endocrinology and Metabolism·Noriteru MoritaHideaki Kawaguchi
Apr 11, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Arend BonenHideo Hatta
Jan 13, 2018·European Journal of Applied Physiology·Brian S FergusonL Bruce Gladden
Aug 6, 2003·American Journal of Physiology. Endocrinology and Metabolism·Yuxiang WangArend Bonen
Aug 20, 2005·Journal of Applied Physiology·S D E SandifordJ Ouyang
Oct 16, 2003·American Journal of Physiology. Endocrinology and Metabolism·Carsten JuelJens Bangsbo
Oct 21, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Claire ThomasGeorge A Brooks
Sep 29, 2019·International Journal of Molecular Sciences·Nami KimHyeon Soo Kim
Apr 27, 2004·Journal of Applied Physiology·Yuko YoshidaArend Bonen
Oct 7, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kathryn H Myburgh

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