PMID: 8941506Nov 1, 1996Paper

Muscle fatigue and exhaustion during dynamic leg exercise in normoxia and hypobaric hypoxia

Journal of Applied Physiology
C S FulcoK B Pandolf

Abstract

Using an exercise device that integrates maximal voluntary static contraction (MVC) of knee extensor muscles with dynamic knee extension, we compared progressive muscle fatigue, i.e., rate of decline in force-generating capacity, in normoxia (758 Torr) and hypobaric hypoxia (464 Torr). Eight healthy men performed exhaustive constant work rate knee extension (21 +/- 3 W, 79 +/- 2 and 87 +/- 2% of 1-leg knee extension O2 peak uptake for normoxia and hypobaria, respectively) from knee angles of 90-150 degrees at a rate of 1 Hz. MVC (90 degrees knee angle) was performed before dynamic exercise and during < or = 5-s pauses every 2 min of dynamic exercise. MVC force was 578 +/- 29 N in normoxia and 569 +/- 29 N in hypobaria before exercise and fell, at exhaustion, to similar levels (265 +/- 10 and 284 +/- 20 N for normoxia and hypobaria, respectively; P > 0.05) that were higher (P < 0.01) than peak force of constant work rate knee extension (98 +/- 10 N, 18 +/- 3% of MVC). Time to exhaustion was 56% shorter for hypobaria than for normoxia (19 +/- 5 vs. 43 +/- 7 min, respectively; P < 0.01), and rate of right leg MVC fall was nearly twofold greater for hypobaria than for normoxia (mean slope = -22.3 vs. -11.9 N/min, respectively; P < ...Continue Reading

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Citations

Dec 24, 2005·Muscle & Nerve·Hans DegensMaria T E Hopman
Nov 29, 2005·European Journal of Applied Physiology·Jon Peter Wehrlin, Jostein Hallén
Jul 11, 2006·Current Sports Medicine Reports·Brett M Loffredo, James L Glazer
May 5, 2007·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Jerald B MoonLili Zhao
Jun 5, 2007·Medicine and Science in Sports and Exercise·Christoph SzubskiWolfgang N Löscher
Sep 25, 2010·Journal of Applied Physiology·John W CastellaniMichael N Sawka
Jul 6, 2012·Acta Physiologica·M J RossmanR S Richardson
Mar 7, 2020·Experimental Physiology·Mark Jacunski, Gerrard F Rafferty
Aug 12, 2006·Journal of Applied Physiology·Christoph SzubskiWolfgang N Löscher
Nov 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keisho KatayamaJerome A Dempsey
Feb 28, 2006·Clinical Science·Charles S FulcoAllen Cymerman
Oct 27, 2007·Journal of Applied Physiology·Markus Amann, Jose A L Calbet
Aug 11, 2010·Pflügers Archiv : European journal of physiology·Hans DegensRob C I Wüst
Jan 17, 2015·Fatigue : Biomedicine, Health & Behavior·Stuart GoodallMarkus Amann
Dec 19, 2009·Medicine and Science in Sports and Exercise·Keisho KatayamaKoji Ishida
Jun 13, 2009·High Altitude Medicine & Biology·Stéphane Perrey, Thomas Rupp
Feb 16, 2013·European Journal of Applied Physiology·Apiwan ManimmanakornMichael J Hamlin
Feb 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Samuel VergesGuillaume Y Millet
Sep 17, 2014·High Altitude Medicine & Biology·Rafael Torres-PeraltaJosé A L Calbet
Feb 12, 2019·Medicine and Science in Sports and Exercise·Fabrice RannouNikolai B Nordsborg
Jan 18, 2020·Scientific Reports·Francis DegacheGrégoire P Millet
Jun 16, 2001·Journal of Applied Physiology·C S FulcoS F Lewis
Mar 19, 2015·Journal of Strength and Conditioning Research·Manabu ShimodaKazuyoshi Yagishita
Mar 2, 2019·European Journal of Applied Physiology·Owen JeffriesMark Waldron
Oct 12, 2004·Muscle & Nerve·Roberto CasaleAlberto Rainoldi
Aug 24, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Markus AmannJerome A Dempsey
Jan 13, 2015·American Journal of Respiratory and Critical Care Medicine·Hans DegensHieronymus W H van Hees
May 13, 2015·European Journal of Applied Physiology·Alex LloydGeorge Havenith
Nov 2, 2014·European Journal of Applied Physiology·Thomas RuppStéphane Perrey
Nov 12, 2021·The Journal of Physiology·Daniel J McKeownJustin J Kavanagh

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