Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice

Aging
Andrea Del CampoEnrique Jaimovich

Abstract

Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial topology and dynamics in the process of muscle aging is not fully understood. This work shows a time line of changes in both mitochondrial distribution and skeletal muscle function during mice lifespan. We isolated muscle fibers from flexor digitorum brevis of mice of different ages. A fusion-like phenotype of mitochondria, together with a change in orientation perpendicular to the fiber axis was evident in the Adult group compared to Juvenile and Older groups. Moreover, an increase in the contact area between sarcoplasmic reticulum and mitochondria was evident in the same group. Together with the morphological changes, mitochondrial Ca2+ resting levels were reduced at age 10-14 months and significantly increased in the Older group. This was consistent with a reduced number of mitochondria-to-jSR pairs in the Older group compared to the Juvenile. Our results support the idea of several age-dependent changes in mitochondria that are accentuated in midlife prior to a complete sarcopenic phenotype.

References

Apr 1, 1985·Clinical Physiology·A YoungM Crowe
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M TsutsumiT Fujita
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·O E RooyackersK S Nair
Apr 26, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·V A HughesM A Fiatarone Singh
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Melanie G CreeRobert R Wolfe
Mar 19, 2005·Journal of Applied Physiology·O Mathieu-CostelloL Cui
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kevin R ShortK Sreekumaran Nair
Nov 29, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jonathan D SchertzerGordon S Lynch
Jan 8, 2008·Biophysical Journal·Ramón Jiménez-MorenoOsvaldo Delbono
Feb 6, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Simona E GrigorescuPeter Kruizinga
Nov 28, 2008·Molecular Biology of the Cell·Simona BoncompagniFeliciano Protasi
May 6, 2009·Biochimica Et Biophysica Acta·Richard M Denton
Apr 20, 2010·The EMBO Journal·Vanina RomanelloMarco Sandri
Sep 15, 2010·The Journal of General Physiology·Mariana CasasEnrique Jaimovich
Jun 4, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christy S CarterDrake Morgan
Aug 2, 2011·Cell Metabolism·Daniel C AnderssonAndrew R Marks
Aug 10, 2011·Clinics in Geriatric Medicine·Irwin H Rosenberg
Apr 4, 2012·Nutrition·Brian C Clark, Todd M Manini
Nov 17, 2012·Biological Chemistry·Riccardo CalvaniEmanuele Marzetti
Jul 13, 2013·The International Journal of Biochemistry & Cell Biology·Emanuele MarzettiChristiaan Leeuwenburgh
Oct 3, 2013·American Journal of Physiology. Endocrinology and Metabolism·Andrea del CampoSergio Lavandero
Jan 29, 2014·Current Molecular Medicine·V CastañedaS Härtel
Apr 23, 2014·The Journal of Cell Biology·Verónica EisnerGyörgy Hajnóczky
May 20, 2014·The International Journal of Biochemistry & Cell Biology·Mitchell BarnsTea Shavlakadze
Jun 19, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marine GueugneauDaniel Béchet
Sep 11, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Tommy Cederholm, John E Morley
Jan 9, 2015·Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases·Valter SantilliMarco Paoloni
Jun 9, 2015·Oncotarget·Jean-Philippe Leduc-GaudetGilles Gouspillou
Jul 15, 2015·Biochimica Et Biophysica Acta·Camila López-CrisostoSergio Lavandero
Aug 1, 2015·Nature·Brian GlancyRobert S Balaban
Oct 21, 2015·Oncotarget·Laura PietrangeloFeliciano Protasi
Feb 10, 2016·The Journal of Cell Biology·Prashant Mishra, David C Chan
Jul 21, 2016·Experimental Gerontology·Ramy K A SayedDarío Acuña-Castroviejo
Nov 3, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giorgos K SakellariouMalcolm J Jackson
Sep 30, 2016·Scientific Reports·Giorgos K SakellariouAnne McArdle

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Citations

Mar 7, 2019·Cellular and Molecular Life Sciences : CMLS·Joseph J ByrneBrent Neumann
Nov 15, 2018·Physiological Reviews·Lars LarssonMarco Sandri
Aug 14, 2018·Current Opinion in Supportive and Palliative Care·Ryan N MontalvoJames A Carson
Dec 20, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hikari TakeshitaHiromi Rakugi
Oct 17, 2019·Cold Spring Harbor Perspectives in Medicine·Anup K Biswas, Swarnali Acharyya
Jun 15, 2019·Journal of Cachexia, Sarcopenia and Muscle·Matthew J MyersStephen E Alway
Jan 30, 2020·Cells·Alessandra StacchiottiLuigi Fabrizio Rodella
Dec 29, 2020·Experimental Physiology·Jenna Wilcox-HagertyDavid L Waning
Nov 2, 2019·Mitochondrion·Aicha MelouaneJonny St-Amand
Oct 30, 2020·Frontiers in Endocrinology·Danielle L KirkmanSalvatore Carbone
Jan 21, 2021·Biochemical and Biophysical Research Communications·Taichi FukunagaKazuhiro Shigemoto
Mar 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mauricio Castro-SepulvedaHermann Zbinden-Foncea
May 1, 2021·International Journal of Environmental Research and Public Health·Shuang-Shuang ZhangJun-Ping Li
Nov 17, 2020·Experimental Gerontology·Stephen D AntonMarco Pahor
Jun 12, 2021·Scientific Reports·Alan Mejia MazaCarole H Sudre
Aug 22, 2021·Trends in Molecular Medicine·Ciarán E FealyMatthijs K C Hesselink
Sep 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pablo E MoralesSergio Lavandero
Sep 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mauricio Castro-SepúlvedaHermann Zbinden-Foncea

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Methods Mentioned

BETA
confocal microscopy
electron microscopy
transgenic
PCR
Assay
electrophoresis

Software Mentioned

GraphPad Prism
MXPro
ImageJ
Fiji

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