PMID: 7542449Apr 1, 1995Paper

Muscle involvement in congenital insensitivity to pain with anhidrosis

Pediatric Neurology
N TachiK Minagawa

Abstract

A patient with congenital insensitivity to pain with anhidrosis, who had characteristic clinical features and biopsied sural nerve, is presented. Nerve pathology findings indicated a loss of the small myelinated and unmyelinated fibers. Biopsied muscle disclosed a marked variation in fiber size, some small fibers with central nuclei, and a small number of small angulated fibers, consistent with neurogenic and myogenic changes. Many patients with congenital insensitivity to pain with anhidrosis had muscle weakness and absent or decreased deep tendon reflexes with normal nerve conduction velocity. We confirmed that lack of small myelinated fibers in motor neurons resulted in a striking change of muscle in our patient.

References

Apr 1, 1988·Archives of Dermatology·N IshiiH Nakajima
Apr 1, 1987·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J S BrahimH D McDonald
Jan 1, 1966·The Journal of Pediatrics·L Pinsky, A M DiGeorge
Feb 1, 1968·Archives of Disease in Childhood·F VassellaO Tönz
May 1, 1980·Muscle & Nerve·E RafelJ Lazo
Nov 1, 1980·Journal of Neuropathology and Experimental Neurology·H H GoebelP J Dyck
Jun 1, 1980·Journal of Developmental and Behavioral Pediatrics : JDBP·A DanielH Dekirmenjian

❮ Previous
Next ❯

Citations

Mar 16, 2012·Experimental Brain Research·Noritaka KawashimaNobuhiko Haga
Jan 7, 2016·Proceedings of the National Academy of Sciences of the United States of America·Muzamil Majid KhanRüdiger Rudolf
Mar 19, 2013·Pediatric Neurology·Zamir ShorerJacov Levy
Mar 24, 1999·American Journal of Ophthalmology·R YagevT Lifshitz
Feb 26, 2008·Archives of Physical Medicine and Rehabilitation·James A SliwaVan Do
Dec 23, 2008·Journal of Pediatric Orthopedics·David S FeldmanFelicia B Axelrod
Feb 22, 2021·Ageing Research Reviews·Osvaldo DelbonoMaria Laura Messi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.