Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear.

Molecular and Cellular Neurosciences
Abdullah A OsmanD D Simmons

Abstract

Nothing is known about the regulation of nicotinic acetylcholine receptors (nAChRs) in hair cells of the inner ear. MuSK, rapsyn and RIC-3 are accessory molecules associated with muscle and brain nAChR function. We demonstrate that these accessory molecules are expressed in the inner ear raising the possibility of a muscle-like mechanism for clustering and assembly of nAChRs in hair cells. We focused our investigations on rapsyn and RIC-3. Rapsyn interacts with the cytoplasmic loop of nAChR alpha9 subunits but not nAChR alpha10 subunits. Although rapsyn and RIC-3 increase nAChR alpha9 expression, rapsyn plays a greater role in receptor clustering while RIC-3 is important for acetylcholine-induced calcium responses. Our data suggest that RIC-3 facilitates receptor function, while rapsyn enhances receptor clustering at the cell surface.

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Citations

Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Isabelle RouxElisabeth Glowatzki
Jan 11, 2011·Journal of Neurochemistry·Victor TsetlinIgor Kasheverov
Jul 24, 2010·The Journal of Comparative Neurology·Dwayne D SimmonsAubrey J Hornak
Jan 7, 2015·The Journal of Comparative Neurology·Paivi M JordanJoseph C Holt
Nov 2, 2011·Biochimica Et Biophysica Acta·Ana S Vallés, Francisco J Barrantes
May 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neerad C MishraMohan L Sopori
Sep 17, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery

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