Muscle Mass Index and Animal Source of Dietary Protein Are Positively Associated with Insulin Resistance in Participants of the NuAge Study

The Journal of Nutrition, Health & Aging
Joane MattaJosé A Morais

Abstract

Contribute evidence towards the complex interrelationships of body composition, insulin sensitivity and protein intake independently from adiposity in an older population. This is a cross-sectional analysis of an existing dataset in which a literature-supported model linking together the variables of interest is tested using path analysis. The loss of muscle mass has been implicated in the development of insulin resistance. We propose to test associations of muscle mass with insulin sensitivity and their respective associations with animal and vegetable sources of protein intake, independently from adiposity. Non-diabetic participants aged 68-82 years from the NuAge study with all available measures (n=441) were included. A model considering age, sex, chronic diseases, physical activity; smoking and sources of protein intake influencing body composition components and insulin sensitivity was created and tested with Path Analysis for their independent associations. Muscle mass index (MMI; kg/height in m2) and % body fat were derived from DXA and BIA. Insulin resistance was estimated by the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) score and physical activity by the Physical Activity Scale for the Elderly (PAS...Continue Reading

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Citations

Dec 8, 2017·PloS One·Ramzi J KhairallahElaine S Krul
Feb 27, 2019·Journal of Nutrition in Gerontology and Geriatrics·Rima Itani Al-Nimr
Apr 3, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Lucas B R OrssattoGabriel S Trajano

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