PMID: 7091311Jun 1, 1982Paper

Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion

The American Journal of Physiology
K J DaviesL Packer

Abstract

Relationships between muscle oxidative capacity, anemia, endurance, whole-body maximal O2 consumption (VO2 max), and VO2 max work load (maximal treadmill speed at 15% grade, rat weight constant) were investigated in iron deficiency and during dietary iron repletion. Young rats were made severely iron deficient by a diet containing 2 mg iron/kg. Control animals received the same diet but with 50 mg iron/kg. Blood hemoglobin was decreased to 3.6 +/- 0.5 g/dl compared to 13.7 +/- 0.6 in control animals. The combination of decreased mitochondrial enzyme specific activities and a 30% reduction in the mitochondrial content of muscle resulted in 60-85% decreases in muscle oxidative capacities. VO2 max and VO2 max work load were both 50% lower in deficient rats, whereas endurance capacity was 90% lower in deficient animals than controls. The iron sufficient control diet was then given to deficient rats and the course of dietary repletion followed. Hemoglobin increased substantially within 3 days in parallel with VO2 max and VO2 max work load. No significant improvements in mitochondrial bioenergetic functions, mitochondrial content of muscle, muscle oxidative capacity, or endurance capacity occurred until the 5th day. We conclude that ...Continue Reading

References

Jul 1, 1979·The Journal of Clinical Investigation·C A FinchB Mackler
Dec 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A Brooks, T P White
Jun 1, 1977·The American Journal of Clinical Nutrition·G W GardnerY Ohira
Aug 1, 1976·The Journal of Clinical Investigation·C A FinchB Mackler
Oct 1, 1965·The Journal of Clinical Investigation·P R Dallman, H C Schwartz
Mar 1, 1980·The American Journal of Clinical Nutrition·M A SiimesP R Dallman
Aug 1, 1980·Pflügers Archiv : European journal of physiology·L D Patch, G A Brooks
Apr 15, 1982·Archives of Biochemistry and Biophysics·K J DaviesG A Brooks
Jul 1, 1981·Archives of Biochemistry and Biophysics·K J DaviesG A Brooks
Jan 1, 1981·The Journal of Nutrition·Y OhiraG A Brooks
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

Citations

Oct 17, 2008·Physiological Reviews·Scott K Powers, Malcolm J Jackson
May 11, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erika KoltaiZsolt Radak
Mar 14, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas C BonneCarsten Lundby
Oct 14, 2017·The Journal of Physiology·Laura C D Pomatto, Kelvin J A Davies
May 17, 2018·Frontiers in Physiology·Kelvin J A Davies
May 1, 2018·Current Heart Failure Reports·Kunal N Bhatt, Javed Butler
Sep 18, 2002·Journal of Applied Physiology·Kyle K HendersonNorberto C Gonzalez
Oct 31, 2014·Journal of Sports Sciences·Angus LindsaySteven P Gieseg
Sep 29, 2007·The Journal of Physiology·Michael J Joyner, Edward F Coyle
May 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·David J BishopJacques Mercier
Feb 15, 2020·Experimental Physiology·Michael J Joyner, Paolo B Dominelli
May 21, 2019·Journal of Cellular Physiology·Aleksandra PaterekMichał Mączewski
Oct 15, 2014·Journal of Cardiopulmonary Rehabilitation and Prevention·Randall E KeyserLeighton Chan

Related Concepts

Cytochromes
Diet
Flavoproteins
Hematocrit Procedure
Eryhem
Iron
Mitochondria, Muscle
Muscle
Oxygen Consumption
Physical Endurance

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