Muscle myosin filaments: cores, crowns and couplings

Biophysics Reviews
John M Squire

Abstract

Myosin filaments in muscle, carrying the ATPase myosin heads that interact with actin filaments to produce force and movement, come in multiple varieties depending on species and functional need, but most are based on a common structural theme. The now successful journeys to solve the ultrastructures of many of these myosin filaments, at least at modest resolution, have not been without their false starts and erroneous sidetracks, but the picture now emerging is of both diversity in the rotational symmetries of different filaments and a degree of commonality in the way the myosin heads are organised in resting muscle. Some of the remaining differences may be associated with how the muscle is regulated. Several proteins in cardiac muscle myosin filaments can carry mutations associated with heart disease, so the elucidation of myosin filament structure to understand the effects of these mutations has a clear and topical clinical relevance.

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Citations

Oct 5, 2019·International Journal of Molecular Sciences·Carlo Knupp, John M Squire
Jul 22, 2019·Journal of Muscle Research and Cell Motility·Felicity EakinsJohn M Squire
Dec 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hind A Al-KhayatEdward P Morris
Mar 15, 2020·Physical Review. E·Justin Grewe, Ulrich S Schwarz
Jul 16, 2010·Meat Science·E Puolanne, Marjo Halonen

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